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In this paper, we introduce a 400-kHz, 55-degree field of view handheld OCT\/OCTA system that has overcome many technical challenges as a portable OCT system as well as a high-speed OCTA system. We demonstrate imaging premature infants with retinopathy of prematurity (ROP) in the NICU, a patient with incontinentia pigmenti (IP), and a patient with X-linked retinoschisis (XLRS) in the OR using our handheld OCT system. Our design may have the potential for improving the diagnosis of retinal diseases and help provide a practical guideline for designing a flexible and portable OCT system.<\/jats:p>","DOI":"10.1364\/boe.425411","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T12:00:19Z","timestamp":1621252819000},"page":"3553","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source"],"prefix":"10.1364","volume":"12","author":[{"given":"Shuibin","family":"Ni","sequence":"first","affiliation":[{"name":"Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-6018","authenticated-orcid":true,"given":"Xiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ringo","family":"Ng","sequence":"additional","affiliation":[{"name":"Simon Fraser University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ostmo","sequence":"additional","affiliation":[{"name":"Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Chiang","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Huang","sequence":"additional","affiliation":[{"name":"Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-1905","authenticated-orcid":true,"given":"Yali","family":"Jia","sequence":"additional","affiliation":[{"name":"Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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