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We demonstrate that, due to the influence of the double-pass confocal OCM imaging geometry on the shape of computed pupil functions, computational sensing of high-order aberrations can suffer from signal attenuation in certain spatial-frequency bands and shape similarity with lower order counterparts. However, by sensing and correcting only low-order aberrations (astigmatism, coma, and trefoil), we still successfully corrected tissue-induced aberrations, leading to 3\u00d7 increase in OCM signal intensity at a depth of \u223c0.9\u2005mm in a freshly dissected <jats:italic toggle=\"yes\">ex vivo<\/jats:italic> mouse brain.<\/jats:p>","DOI":"10.1364\/boe.427979","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T10:30:13Z","timestamp":1624962613000},"page":"4934","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Closed-loop wavefront sensing and correction in the mouse brain with computed optical coherence microscopy"],"prefix":"10.1364","volume":"12","author":[{"given":"Siyang","family":"Liu","sequence":"first","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-8769","authenticated-orcid":true,"given":"Fei","family":"Xia","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-6299","authenticated-orcid":true,"given":"Xusan","family":"Yang","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A.","family":"Bizimana","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Xu","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Adie","sequence":"additional","affiliation":[{"name":"Cornell University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"boe-12-8-4934-R1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1073\/pnas.1109202108","volume":"109","author":"Ji","year":"2012","journal-title":"Proc. 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