{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:34:09Z","timestamp":1792802049556,"version":"4.5.0"},"reference-count":48,"publisher":"Optica Publishing Group","issue":"4","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/22\/A\/ST2\/00313"],"award-info":[{"award-number":["2016\/22\/A\/ST2\/00313"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/38\/L\/ST2\/00556"],"award-info":[{"award-number":["2020\/38\/L\/ST2\/00556"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki Polskiej","doi-asserted-by":"publisher","award":["MAB\/2019\/12"],"award-info":[{"award-number":["MAB\/2019\/12"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki Polskiej","doi-asserted-by":"publisher","award":["POIR.04.04.00-00-3D47\/16-00"],"award-info":[{"award-number":["POIR.04.04.00-00-3D47\/16-00"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lietuvos mokslo taryba DAINA2 \u2013 Polish-Lithuanian Funding Initiative","award":["P-LL-21-100"],"award-info":[{"award-number":["P-LL-21-100"]}],"id":[{"id":"https:\/\/ror.org\/02gs16m83","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p>\n                    For many years electroretinography (ERG) has been used for obtaining information about the retinal physiological function. More recently, a new technique called optoretinography (ORG) has been developed. In one form of this technique, the physiological response of retinal photoreceptors to visible light, resulting in a nanometric photoreceptor optical path length change, is measured by phase-sensitive optical coherence tomography (OCT). To date, a limited number of studies with phase-based ORG measured the retinal response to a flickering light stimulation. In this work, we use a spatio-temporal optical coherence tomography (STOC-T) system to capture optoretinograms with a flickering stimulus over a 1.7\u2009\u00d7\u20090.85 mm\n                    <jats:sup>2<\/jats:sup>\n                    area of a light-adapted retina located between the fovea and the optic nerve. We show that we can detect statistically-significant differences in the photoreceptor optical path length (OPL) modulation amplitudes in response to different flicker frequencies and with better signal to noise ratios (SNRs) than for a dark-adapted eye. We also demonstrate the ability to spatially map such response to a patterned stimulus with light stripes flickering at different frequencies, highlighting the prospect of characterizing the spatially-resolved temporal-frequency response of the retina with ORG.\n                  <\/jats:p>","DOI":"10.1364\/boe.444567","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T02:00:08Z","timestamp":1645668008000},"page":"2186","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Light-adapted flicker optoretinograms captured with a spatio-temporal optical coherence-tomography (STOC-T) system"],"prefix":"10.1364","volume":"13","author":[{"given":"S\u0142awomir","family":"Tomczewski","sequence":"first","affiliation":[{"name":"International Centre for Translational Eye Research"},{"name":"Institute of Physical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-6722","authenticated-orcid":true,"given":"Piotr","family":"W\u0119grzyn","sequence":"additional","affiliation":[{"name":"International Centre for Translational Eye Research"},{"name":"Institute of Physical Chemistry"},{"name":"University of Warsaw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-889X","authenticated-orcid":true,"given":"Dawid","family":"Borycki","sequence":"additional","affiliation":[{"name":"International Centre for Translational Eye Research"},{"name":"Institute of Physical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-067X","authenticated-orcid":true,"given":"Egidijus","family":"Auksorius","sequence":"additional","affiliation":[{"name":"International Centre for Translational Eye Research"},{"name":"Institute of Physical Chemistry"},{"name":"Center for Physical Sciences and Technology (FTMC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Wojtkowski","sequence":"additional","affiliation":[{"name":"International Centre for Translational Eye Research"},{"name":"Institute of Physical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-0074","authenticated-orcid":true,"given":"Andrea","family":"Curatolo","sequence":"additional","affiliation":[{"name":"International Centre for Translational Eye Research"},{"name":"Institute of Physical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"boe-13-4-2186-R1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.ajo.2003.12.035","volume":"137","author":"Yannuzzi","year":"2004","journal-title":"Am. 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