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Opt. Express"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>Irregular ocular pulsatility and altered mechanical tissue properties\n\t\t\t\t\tare associated with some of the most sight-threatening eye diseases.\n\t\t\t\t\tHere we present 4D optical coherence tomography (OCT) for the\n\t\t\t\t\tquantitative assessment and depth-resolved mapping of pulsatile\n\t\t\t\t\tdynamics in the murine retina and choroid. Through a pixel-wise\n\t\t\t\t\tanalysis of phase changes of the complex OCT signal, we reveal\n\t\t\t\t\tspatiotemporal displacement characteristics across repeated frame\n\t\t\t\t\tacquisitions. We demonstrate in vivo fundus elastography (FUEL)\n\t\t\t\t\timaging in wildtype mouse retinas and in a mouse model of retinal\n\t\t\t\t\tneovascularization and uncover subtle structural deformations related\n\t\t\t\t\tto ocular pulsation. Our data in mouse eyes hold promise for a\n\t\t\t\t\tpowerful retinal elastography technique that may enable a new paradigm\n\t\t\t\t\tof OCT-based measurements and image contrast.<\/jats:p>","DOI":"10.1364\/boe.445093","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T10:00:06Z","timestamp":1640772006000},"page":"647","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography"],"prefix":"10.1364","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-1932","authenticated-orcid":true,"given":"Bernhard","family":"Baumann","sequence":"first","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-4100","authenticated-orcid":true,"given":"Conrad W.","family":"Merkle","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-0907","authenticated-orcid":true,"given":"Marco","family":"Augustin","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-3247","authenticated-orcid":true,"given":"Martin","family":"Gl\u00f6smann","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Garh\u00f6fer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"285","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"boe-13-2-647-R1","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1016\/0039-6257(94)90049-3","volume":"38","author":"Silver","year":"1994","journal-title":"Surv.\n\t\t\t\t\tOphthalmol."},{"key":"boe-13-2-647-R2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S0161-6420(89)32936-8","volume":"96","author":"Friedman","year":"1989","journal-title":"Ophthalmology"},{"key":"boe-13-2-647-R3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00417-002-0460-4","volume":"240","author":"Evans","year":"2002","journal-title":"Graefe\u2019s Arch. 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Further distribution of\n\t\t\t\t\tthis work must maintain attribution to the author(s) and the published\n\t\t\t\t\tarticle\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}