{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:32:16Z","timestamp":1790101936471,"version":"4.0.1"},"reference-count":34,"publisher":"Optica Publishing Group","issue":"5","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1119534"],"award-info":[{"award-number":["OPP1119534"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anne Potter Wilson Foundation Vanderbilt Institute of Global Health Award"}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p>Newborns in high-income countries are routinely screened for neonatal jaundice using transcutaneous bilirubinometery (TcB). In low-and middle-income countries, TcB is not widely used due to a lack of availability; however, mobile-phone approaches for TcB could help expand screening opportunities. We developed a mobile phone-based approach for TcB and validated the method with a 37 patient multi-ethnic pilot study. We include a custom-designed snap-on adapter that is used to create a spatially resolved diffuse reflectance detection configuration with the illumination provided by the mobile-phone LED flash. Monte-Carlo models of reflectance from neonatal skin were used to guide the design of an adapter for filtered red-green-blue (RGB) mobile-phone camera reflectance measurements. We extracted measures of reflectance from multiple optimized spatial-offset regions-of-interest (ROIs) and a linear model was developed and cross-validated. This resulted in a correlation between total serum bilirubin and mobile-phone TcB estimated bilirubin with a <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= 0.42 and Bland-Altman limits of agreement of +6.4 mg\/dL to -7.0 mg\/dL. These results indicate that a mobile phone with a modified adapter can be utilized to measure neonatal bilirubin values, thus creating a novel tool for neonatal jaundice screening in low-resource settings.<\/jats:p>","DOI":"10.1364\/boe.449625","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T20:00:26Z","timestamp":1648843226000},"page":"2797","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a mobile phone camera-based transcutaneous bilirubinometer for low-resource settings"],"prefix":"10.1364","volume":"13","author":[{"given":"Brandon","family":"Harrison-Smith","sequence":"first","affiliation":[{"name":"Temple University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.","family":"Dumont","sequence":"additional","affiliation":[{"name":"Temple University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Shahriar","family":"Arefin","sequence":"additional","affiliation":[{"name":"Temple University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Temple University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuradeen","family":"Lawal","sequence":"additional","affiliation":[{"name":"Aminu Kano Teaching Hospital(AKTH)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorianna","family":"Dobson","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center(VUMC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nwaba","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center(VUMC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Grossarth","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center(VUMC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsalam Muhammed","family":"Paed","sequence":"additional","affiliation":[{"name":"Aminu Kano Teaching Hospital(AKTH)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubaida L.","family":"Farouk","sequence":"additional","affiliation":[{"name":"Aminu Kano Teaching Hospital(AKTH)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorn-Hendrik","family":"Weitkamp","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center(VUMC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan A.","family":"Patil","sequence":"additional","affiliation":[{"name":"Temple University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"boe-13-5-2797-R2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.4254\/wjh.v11.i3.287","volume":"11","author":"Haydek","year":"2019","journal-title":"World J. 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Further distribution of this work must maintain attribution to the author(s) and the published article\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}