{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:25:24Z","timestamp":1790997924386,"version":"4.1.0"},"reference-count":58,"publisher":"Optica Publishing Group","issue":"10","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of\n\t\t\t\t\t\tHealth","doi-asserted-by":"publisher","award":["R01-EB027653"],"award-info":[{"award-number":["R01-EB027653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of\n\t\t\t\t\t\tHealth","doi-asserted-by":"publisher","award":["R42-EY028820"],"award-info":[{"award-number":["R42-EY028820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie\n\t\t\t\t\t\tActions","doi-asserted-by":"publisher","award":["H2020-MSCA-IF-GF-2019-MYOMICRO-893557"],"award-info":[{"award-number":["H2020-MSCA-IF-GF-2019-MYOMICRO-893557"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p>\n                    Scleral crosslinking may provide a way to prevent or treat myopia by\n\t\t\t\t\tstiffening scleral tissues. The ability to measure the stiffness of\n\t\t\t\t\tscleral tissues\n                    <jats:italic>in situ<\/jats:italic>\n                    pre and post scleral\n\t\t\t\t\tcrosslinking would be useful but has not been established. Here, we\n\t\t\t\t\ttested the feasibility of optical coherence elastography (OCE) to\n\t\t\t\t\tmeasure shear modulus of scleral tissues and evaluate the impact of\n\t\t\t\t\tcrosslinking on different posterior scleral regions using\n                    <jats:italic>ex\n\t\t\t\t\tvivo<\/jats:italic>\n                    porcine eyes as a model. From measured elastic wave\n\t\t\t\t\tspeeds at 6 - 16 kHz, we obtained out-of-plane shear modulus value of\n\t\t\t\t\t0.71\u2009\u00b1\u20090.12 MPa (n\u2009=\u200920) for\n\t\t\t\t\tnormal porcine scleral tissues. After riboflavin-assisted UV\n\t\t\t\t\tcrosslinking, the shear modulus increased to\n\t\t\t\t\t1.50\u2009\u00b1\u20090.39 MPa (n\u2009=\u200920).\n\t\t\t\t\tThis 2-fold change was consistent with the increase of static\n\t\t\t\t\tYoung\u2019s modulus from 5.5\u2009\u00b1\u20091.1 MPa to\n\t\t\t\t\t9.3\u2009\u00b1\u20091.9 MPa after crosslinking, which we\n\t\t\t\t\tmeasured using conventional uniaxial extensometry on tissue stripes.\n\t\t\t\t\tOCE revealed regional stiffness differences across the temporal,\n\t\t\t\t\tnasal, and deeper posterior sclera. Our results show the potential of\n\t\t\t\t\tOCE as a noninvasive tool to evaluate the effect of scleral\n\t\t\t\t\tcrosslinking.\n                  <\/jats:p>","DOI":"10.1364\/boe.463600","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T03:00:07Z","timestamp":1660186807000},"page":"5434","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["In situ measurement of the stiffness increase in the posterior sclera after UV-riboflavin crosslinking by optical coherence elastography"],"prefix":"10.1364","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-9508","authenticated-orcid":true,"given":"Maria","family":"Vinas-Pena","sequence":"first","affiliation":[{"name":"Wellman Center for Photomedicine and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-7144","authenticated-orcid":true,"given":"Xu","family":"Feng","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-yang","family":"Li","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hyun","family":"Yun","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"boe-13-10-5434-R1","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"boe-13-10-5434-R2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/519276a","volume":"519","author":"Dolgin","year":"2015","journal-title":"Nature"},{"key":"boe-13-10-5434-R3","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.preteyeres.2012.06.004","volume":"31","author":"Flitcroft","year":"2012","journal-title":"Prog. 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Opt.\n\t\t\t\t\tExpress"},{"key":"boe-13-10-5434-R40","doi-asserted-by":"publisher","first-page":"e0165669","DOI":"10.1371\/journal.pone.0165669","volume":"11","author":"Bekesi","year":"2016","journal-title":"PLoS One"},{"key":"boe-13-10-5434-R41","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3389\/fbioe.2018.00210","volume":"6","author":"Nguyen","year":"2019","journal-title":"Front. Bioeng.\n\t\t\t\t\tBiotechnol."},{"key":"boe-13-10-5434-R42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.61.13.7","volume":"61","author":"Zvietcovich","year":"2020","journal-title":"Invest.\n\t\t\t\t\tOphthalmol. Vis. Sci."},{"key":"boe-13-10-5434-R43","doi-asserted-by":"publisher","first-page":"17366","DOI":"10.1038\/s41598-020-74383-4","volume":"10","author":"Ramier","year":"2020","journal-title":"Sci. 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Ophthalmol.\n\t\t\t\t\tVisual Sci."},{"key":"boe-13-10-5434-R59","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1139\/o96-080","volume":"74","author":"Chiquet","year":"1996","journal-title":"Biochem. Cell Biol."},{"key":"boe-13-10-5434-R60","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1167\/iovs.17-21559","volume":"58","author":"Kwok","year":"2017","journal-title":"Invest. Ophthalmol.\n\t\t\t\t\tVisual Sci."}],"container-title":["Biomedical Optics Express"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=boe-13-10-5434&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:29:41Z","timestamp":1722958181000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=boe-13-10-5434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1364\/boe.463600","relation":{},"ISSN":["2156-7085","2156-7085"],"issn-type":[{"value":"2156-7085","type":"print"},{"value":"2156-7085","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/BOE.463600","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"research-article","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"10 May 2022","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"9 August 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"23 September 2022","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2022 Optica Publishing Group under the terms\n\t\t\t\t\tof the Optica Open\n\t\t\t\t\tAccess Publishing Agreement","name":"copyright","label":"Copyright"}]}}