{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:12:29Z","timestamp":1787962349266,"version":"build-2784847793"},"reference-count":55,"publisher":"Optica Publishing Group","issue":"7","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence\n\t\t\t\t\t\tFund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health\n\t\t\t\t\t\tResearch","doi-asserted-by":"publisher","award":["446387"],"award-info":[{"award-number":["446387"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research\n\t\t\t\t\t\tCouncil of Canada","doi-asserted-by":"publisher","award":["312037"],"award-info":[{"award-number":["312037"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:p>\n                    <jats:italic>In-vivo<\/jats:italic>\n                    , non-contact, volumetric imaging of the\n\t\t\t\t\tcellular and sub-cellular structure of the human cornea and limbus\n\t\t\t\t\twith optical coherence tomography (OCT) is challenging due to\n\t\t\t\t\tinvoluntary eye motion that introduces both motion artifacts and blur\n\t\t\t\t\tin the OCT images. Here we present the design of a line-scanning (LS)\n\t\t\t\t\tspectral-domain (SD) optical coherence tomography system that combines\n\t\t\t\t\t2 \u00d7 3 \u00d7 1.7 \u00b5m (x, y, z) resolution in biological\n\t\t\t\t\ttissue with an image acquisition rate of \u223c2,500 fps, and\n\t\t\t\t\tdemonstrate its ability to image\n                    <jats:italic>in-vivo<\/jats:italic>\n                    and without\n\t\t\t\t\tcontact with the tissue surface, the cellular structure of the human\n\t\t\t\t\tanterior segment tissues. Volumetric LS-SD-OCT images acquired over a\n\t\t\t\t\tfield-of-view (FOV) of 0.7 mm \u00d7 1.4 mm reveal fine\n\t\t\t\t\tmorphological details in the healthy human cornea, such as epithelial\n\t\t\t\t\tand endothelial cells, sub-basal nerves, as well as the cellular\n\t\t\t\t\tstructure of the limbal crypts, the palisades of Vogt (POVs) and the\n\t\t\t\t\tblood microvasculature of the human limbus. LS-SD-OCT is a promising\n\t\t\t\t\ttechnology that can assist ophthalmologists with the early diagnostics\n\t\t\t\t\tand optimal treatment planning of ocular diseases affecting the human\n\t\t\t\t\tanterior eye.\n                  <\/jats:p>","DOI":"10.1364\/boe.465916","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T03:00:07Z","timestamp":1654830007000},"page":"4007","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Line-scanning SD-OCT for in-vivo, non-contact, volumetric, cellular resolution imaging of the human cornea and limbus"],"prefix":"10.1364","volume":"13","author":[{"given":"Le","family":"Han","sequence":"first","affiliation":[{"name":"University of Waterloo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-9603","authenticated-orcid":true,"given":"Bingyao","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Waterloo"},{"name":"Nanyang Technological University"},{"name":"SERI-NTU Advanced Ocular Engineering (STANCE)"},{"name":"Singapore National Eye Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Hosseinaee","sequence":"additional","affiliation":[{"name":"University of Waterloo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Waterloo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Hileeto","sequence":"additional","affiliation":[{"name":"University of Waterloo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-5272","authenticated-orcid":true,"given":"Kostadinka","family":"Bizheva","sequence":"additional","affiliation":[{"name":"University of Waterloo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"boe-13-7-4007-R1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.4103\/0301-4738.100540","volume":"60","author":"Oliva","year":"2012","journal-title":"Indian J\n\t\t\t\t\tOphthalmol"},{"key":"boe-13-7-4007-R2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2009.11.001","volume":"29","author":"Niederer","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"boe-13-7-4007-R3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1117\/1.1629679","volume":"9","author":"Drexler","year":"2004","journal-title":"J Biomed Opt"},{"key":"boe-13-7-4007-R4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.preteyeres.2018.04.002","volume":"66","author":"Ang","year":"2018","journal-title":"Prog Retin Eye\n\t\t\t\t\tRes"},{"key":"boe-13-7-4007-R5","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1364\/BOE.2.003037","volume":"2","author":"Yadav","year":"2011","journal-title":"Biomed. 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