{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:30:23Z","timestamp":1790728223923,"version":"4.1.0"},"reference-count":63,"publisher":"Optica Publishing Group","issue":"12","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of\n\t\t\t\t\t\tChina","doi-asserted-by":"publisher","award":["62275201"],"award-info":[{"award-number":["62275201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Joint Funds of the National Natural\n\t\t\t\t\t\tScience Foundation of China","doi-asserted-by":"crossref","award":["U22A20312"],"award-info":[{"award-number":["U22A20312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p>\n                    Lens biomechanics has great potential for application in clinical\n\t\t\t\t\tdiagnostics and treatment monitoring of presbyopia and cataracts.\n\t\t\t\t\tHowever, current approaches to lens elastography do not meet the\n\t\t\t\t\tdesired safety or sensitivity for clinical application. In this\n\t\t\t\t\tregard, we propose a noncontact optical coherence elastography (OCE)\n\t\t\t\t\tmethod to facilitate quantitative\n                    <jats:italic>in situ<\/jats:italic>\n                    imaging of\n\t\t\t\t\tlens elasticity. Elastic waves induced by air-pulse stimulation on the\n\t\t\t\t\tlimbus propagate to the lens and are then imaged using custom-built\n\t\t\t\t\tswept-source optical coherence tomography to obtain the elastic wave\n\t\t\t\t\tvelocity and Young\u2019s modulus. The proposed OCE method was first\n\t\t\t\t\tvalidated by comparing the results of\n                    <jats:italic>in situ<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    measurements of porcine lenses. The results\n\t\t\t\t\tdemonstrate that the Young\u2019s modulus measured\n                    <jats:italic>in\n\t\t\t\t\tsitu<\/jats:italic>\n                    was highly consistent with that measured\n                    <jats:italic>in\n\t\t\t\t\tvitro<\/jats:italic>\n                    and had an intraclass correlation coefficient of 0.988.\n\t\t\t\t\tWe further investigated the elastic changes induced by cold storage\n\t\t\t\t\tand microwave heating. During 36-hour cold storage, the mean\n\t\t\t\t\tYoung\u2019s modulus gradually increased (from\n\t\t\t\t\t5.62\u2009\u00b1\u20091.24 kPa to\n\t\t\t\t\t11.40\u2009\u00b1\u20092.68 kPa, P\u2009&lt;\u20090.0001,\n\t\t\t\t\tn\u2009=\u20099) along with the formation of nuclear\n\t\t\t\t\topacities. 15-second microwave heating caused a greater increase in\n\t\t\t\t\tthe mean Young\u2019s modulus (from 6.86\u2009\u00b1\u20091.21\n\t\t\t\t\tkPa to 25.96\u2009\u00b1\u20098.64 kPa,\n\t\t\t\t\tP\u2009&lt;\u20090.0025, n\u2009=\u20096) without\n\t\t\t\t\tapparent cataract formation. Accordingly, this study reports the first\n\t\t\t\t\tair-pulse OCE measurements of\n                    <jats:italic>in situ<\/jats:italic>\n                    lenses, which\n\t\t\t\t\tquantified the loss of lens elasticity during simulated cataract\n\t\t\t\t\tdevelopment with good repeatability and sensitivity, thus enhancing\n\t\t\t\t\tthe potential for adoption of lens biomechanics in the clinic.\n                  <\/jats:p>","DOI":"10.1364\/boe.475306","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T11:00:08Z","timestamp":1669028408000},"page":"6671","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["In situ assessment of lens elasticity with noncontact optical coherence elastography"],"prefix":"10.1364","volume":"13","author":[{"given":"Yulei","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Ye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiao","family":"Shen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-2088","authenticated-orcid":true,"given":"Dexi","family":"Zhu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Optometry, Ophthalmology, and Vision Science"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"boe-13-12-6671-R1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.preteyeres.2015.02.002","volume":"47","author":"Iribarren","year":"2015","journal-title":"Prog. 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