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Opt. Express"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:p>The balance of ON\/OFF pathway activation in the retina plays a role in emmetropization. A new myopia control lens design uses contrast reduction to down-regulate a hypothesized enhanced ON contrast sensitivity in myopes. The study thus examined ON\/OFF receptive field processing in myopes and non-myopes and the impact of contrast reduction. A psychophysical approach was used to measure the combined retinal-cortical output in the form of low-level ON and OFF contrast sensitivity with and without contrast reduction in 22 participants. ON responses were lower than OFF responses (ON 1.25 \u00b1 0.03 vs. OFF 1.39 \u00b1 0.03\u2009log(CS); p\u2009&lt;\u20090.0001) and myopes showed generally reduced sensitivities (myopes 1.25 \u00b1 0.05 vs. non-myopes 1.39 \u00b1 0.05\u2009log(CS); p\u2009=\u20090.05). These findings remained unaffected by contrast reduction (p\u2009&gt;\u20090.05). The study suggests that perceptual differences in ON and OFF signal processing between myopes and non-myopes exist but cannot explain how contrast reduction can inhibit myopia development.<\/jats:p>","DOI":"10.1364\/boe.489117","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T06:00:47Z","timestamp":1681711247000},"page":"2618","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["ON and OFF receptive field processing in the presence of optical scattering"],"prefix":"10.1364","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-3745","authenticated-orcid":true,"given":"Katharina","family":"Breher","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02mp31p96","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Institute for Ophthalmic Research, University of T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Neumann","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research, University of T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Kurth","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research, University of T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-0811","authenticated-orcid":true,"given":"Frank","family":"Schaeffel","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research, University of T\u00fcbingen"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-6711","authenticated-orcid":true,"given":"Siegfried","family":"Wahl","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02mp31p96","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Institute for Ophthalmic Research, University of T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"boe-14-6-2618-R1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0166-2236(95)94496-R","volume":"18","author":"DeAngelis","year":"1995","journal-title":"Trends Neurosci."},{"key":"boe-14-6-2618-R2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0042-6989(99)00184-4","volume":"40","author":"Smith","year":"2000","journal-title":"Vision Res."},{"key":"boe-14-6-2618-R3","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1113\/jphysiol.2012.243683","volume":"591","author":"Hashimoto","year":"2013","journal-title":"The J. 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Further distribution of this work must maintain attribution to the author(s) and the published article\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}