{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:20:53Z","timestamp":1783682453839,"version":"3.55.0"},"reference-count":53,"publisher":"Optica Publishing Group","issue":"8","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>\n                    Quantifying human crystalline lens geometry as a function of age and accommodation is important for improved cataract and presbyopia treatments. In previous works we presented\n                    <jats:italic>eigenlenses<\/jats:italic>\n                    as a basis of 3-D functions to represent the full shape of the crystalline lens\n                    <jats:italic>ex vivo<\/jats:italic>\n                    . Also, we presented the application of\n                    <jats:italic>eigenlenses<\/jats:italic>\n                    to estimate the full shape of the lens\n                    <jats:italic>in vivo<\/jats:italic>\n                    from 3-D optical coherence tomography (OCT) images, where only the central part of the lens -visible through the pupil- is available. The current work presents a validation of the use of\n                    <jats:italic>eigenlenses<\/jats:italic>\n                    to estimate\n                    <jats:italic>in vivo<\/jats:italic>\n                    the full shape of dis-accommodated lenses. We used 14\n                    <jats:italic>ex vivo<\/jats:italic>\n                    crystalline lenses from donor eyes (11-54 y\/o) mounted in a lens stretcher, and measured the geometry and the power of the lenses using a combined OCT and ray tracing aberrometry system.\n                    <jats:italic>Ex vivo<\/jats:italic>\n                    , the full extent of the lens is accessible from OCT because the incident light is not blocked by the iris. We measured in non-stretched (fully accommodated) and stretched (mimicking\n                    <jats:italic>in vivo<\/jats:italic>\n                    dis-accommodated lenses) conditions. Then, we simulated computationally\n                    <jats:italic>in vivo<\/jats:italic>\n                    conditions on the obtained\n                    <jats:italic>ex vivo<\/jats:italic>\n                    lenses geometry (assuming that just the portion of the lens within a given pupil is available), and estimated the full shape using\n                    <jats:italic>eigenlenses.<\/jats:italic>\n                    The mean absolute error (MAE) between estimated and measured lens\u2019 diameters and volumes were MAE\u2009=\u20090.26\u2009\u00b1\u20090.18 mm and MAE\u2009=\u20097.0\u2009\u00b1\u20094.5 mm\n                    <jats:sup>3<\/jats:sup>\n                    , respectively. Furthermore, we concluded that the estimation error between measured and estimated lenses did not depend on the accommodative state (change in power due to stretching), and thus\n                    <jats:italic>eigenlenses<\/jats:italic>\n                    are also useful for the full shape estimation of\n                    <jats:italic>in vivo<\/jats:italic>\n                    dis-accommodated lenses.\n                  <\/jats:p>","DOI":"10.1364\/boe.493795","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T04:00:09Z","timestamp":1687233609000},"page":"4261","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Estimation of the full shape of the crystalline lens from OCT: validation using stretched donor lenses"],"prefix":"10.1364","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-8846","authenticated-orcid":true,"given":"Eduardo","family":"Mart\u00ednez-Enr\u00edquez","sequence":"first","affiliation":[{"name":"Instituto de \u00d3ptica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Maceo Heilman","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine"},{"name":"University of Miami College of Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-3412","authenticated-orcid":true,"given":"Alberto","family":"de Castro","sequence":"additional","affiliation":[{"name":"Instituto de \u00d3ptica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-4930","authenticated-orcid":true,"given":"Ashik","family":"Mohamed","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute"},{"name":"Brien Holden Vision Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-8476","authenticated-orcid":true,"given":"Marco","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-4168","authenticated-orcid":true,"given":"Fernando","family":"Zvietcovich","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica del Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Manns","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine"},{"name":"University of Miami College of Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-1697","authenticated-orcid":true,"given":"Susana","family":"Marcos","sequence":"additional","affiliation":[{"name":"Instituto de \u00d3ptica"},{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"boe-14-8-4261-R2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1146\/annurev-bioeng-082420-035827","volume":"23","author":"Marcos","year":"2021","journal-title":"Annu Rev Biomed Eng"},{"key":"boe-14-8-4261-R3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40662-017-0077-7","volume":"4","author":"Ali\u00f3","year":"2017","journal-title":"Eye and Vision"},{"key":"boe-14-8-4261-R4","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1364\/OPTICA.6.001050","volume":"6","author":"de la Hoz","year":"2019","journal-title":"Optica"},{"key":"boe-14-8-4261-R5","doi-asserted-by":"publisher","first-page":"10781","DOI":"10.4081\/ejtm.2022.10781","volume":"32","author":"Haghpanah","year":"2022","journal-title":"Eur J Transl Myol"},{"key":"boe-14-8-4261-R6","doi-asserted-by":"publisher","first-page":"25551","DOI":"10.1038\/srep25551","volume":"6","author":"Tabernero","year":"2016","journal-title":"Sci. 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