{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:31:03Z","timestamp":1785411063336,"version":"3.56.0"},"reference-count":32,"publisher":"Optica Publishing Group","issue":"7","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QA063"],"award-info":[{"award-number":["ZR2020QA063"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MF065"],"award-info":[{"award-number":["ZR2021MF065"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021ZD40"],"award-info":[{"award-number":["ZR2021ZD40"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12204273"],"award-info":[{"award-number":["12204273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>\n                    Light can trigger electrical activity in certain types of cells, and is considered to be a better means of biological regulation than electrical stimulation in the future. Due to the specificity and selectivity of natural cells\u2019 photoresponse to optical signals, constructing an applicable method to explore which kinds of cells have photosensitivity and which bands of light could induce its photoresponse most effectively, is of great significance for lights\u2019 medical applications. This paper firstly proposed a universal and operable system and corresponding method to quantitatively measure and analyze photosensitivity of cells in vitro to weak pulse laser, which is constructed with Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging module, adjustable laser lights module and laser positioning module. With the measurement system and method, the photosensitive effects of the natural spiral ganglion cells (SGCs) of mice are tested systemantically. Then a new photoresponse band of light (453\u2005nm, 300 \u00b5s) is found for SGCs, and its minimum threshold is measured as 5.3 mJ\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . The results verify that the proposed method is applicable to screen the cells with photosensitive response, as well as to measure and analyze the working optical parameters, thus is beneficial for the optical biophysics and photobiology.\n                  <\/jats:p>","DOI":"10.1364\/boe.494620","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T03:00:08Z","timestamp":1686711608000},"page":"3584","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In-vitro quantitative measurement and analysis of the photosensitivity of cells to a weak pulse laser"],"prefix":"10.1364","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-334X","authenticated-orcid":true,"given":"Lan","family":"Tian","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-8249","authenticated-orcid":true,"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Tian","sequence":"additional","affiliation":[{"name":"Shandong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-547X","authenticated-orcid":true,"given":"Jingjing","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"boe-14-7-3584-R1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.NPh.5.4.045002","volume":"5","author":"Xu","year":"2018","journal-title":"Neurophotonics"},{"key":"boe-14-7-3584-R2","doi-asserted-by":"publisher","first-page":"13273","DOI":"10.1038\/srep13273","volume":"5","author":"Tan","year":"2015","journal-title":"Sci. Rep."},{"key":"boe-14-7-3584-R3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1364\/OL.30.000504","volume":"30","author":"Wells","year":"2005","journal-title":"Opt. Lett."},{"key":"boe-14-7-3584-R4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/lsm.20358","volume":"38","author":"Izzo","year":"2006","journal-title":"Lasers Surg. Med."},{"key":"boe-14-7-3584-R5","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.heares.2014.03.008","volume":"311","author":"Richter","year":"2014","journal-title":"Hear. Res."},{"key":"boe-14-7-3584-R6","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1529\/biophysj.107.117150","volume":"94","author":"Izzo","year":"2008","journal-title":"Biophys. J."},{"key":"boe-14-7-3584-R7","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1109\/TBME.2007.892925","volume":"54","author":"Izzo","year":"2007","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"boe-14-7-3584-R8","doi-asserted-by":"publisher","first-page":"064003","DOI":"10.1117\/1.2121772","volume":"10","author":"Wells","year":"2005","journal-title":"J. Biomed. Opt."},{"key":"boe-14-7-3584-R9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jneumeth.2007.03.016","volume":"163","author":"Wells","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"boe-14-7-3584-R10","doi-asserted-by":"publisher","first-page":"a034371","DOI":"10.1101\/cshperspect.a034371","volume":"9","author":"Ye","year":"2019","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"boe-14-7-3584-R11","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1007\/s11427-020-1858-1","volume":"63","author":"Luo","year":"2020","journal-title":"Sci. China: Life Sci."},{"key":"boe-14-7-3584-R12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.neuroscience.2020.09.022","volume":"449","author":"Bansal","year":"2020","journal-title":"Neuroscience"},{"key":"boe-14-7-3584-R13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuron.2011.06.004","volume":"71","author":"Yizhar","year":"2011","journal-title":"Neuron"},{"key":"boe-14-7-3584-R14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1049\/htl.2019.0114","volume":"7","author":"Richardson","year":"2020","journal-title":"Healthcare Technology Letters"},{"key":"boe-14-7-3584-R15","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1109\/TBME.2016.2636149","volume":"65","author":"Xia","year":"2018","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"boe-14-7-3584-R16","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.neuron.2012.02.011","volume":"73","author":"Grienberger","year":"2012","journal-title":"Neuron"},{"key":"boe-14-7-3584-R17","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41598-017-18814-9","volume":"8","author":"Tan","year":"2018","journal-title":"Sci. Rep."},{"key":"boe-14-7-3584-R18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.NPh.6.3.035009","volume":"6","author":"Jiang","year":"2019","journal-title":"Neurophotonics"},{"key":"boe-14-7-3584-R19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.heares.2008.01.011","volume":"242","author":"Richter","year":"2008","journal-title":"Hear. Res."},{"key":"boe-14-7-3584-R20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.heares.2010.06.021","volume":"269","author":"Rajguru","year":"2010","journal-title":"Hear. Res."},{"key":"boe-14-7-3584-R21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s10103-016-2123-4","volume":"32","author":"Tian","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"boe-14-7-3584-R22","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10103-016-2129-y","volume":"32","author":"Wang","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"boe-14-7-3584-R23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12938-015-0084-7","volume":"14","author":"Wang","year":"2015","journal-title":"BioMed Eng OnLine"},{"key":"boe-14-7-3584-R24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s11658-022-00316-w","volume":"27","author":"Liu","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"boe-14-7-3584-R25","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","volume":"16","author":"Dana","year":"2019","journal-title":"Nat. Methods"},{"key":"boe-14-7-3584-R26","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"boe-14-7-3584-R28","doi-asserted-by":"publisher","first-page":"044007","DOI":"10.1117\/1.3174389","volume":"14","author":"Wenzel","year":"2009","journal-title":"J. Biomed. Opt."},{"key":"boe-14-7-3584-R29","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/ncomms1742","volume":"3","author":"Shapiro","year":"2012","journal-title":"Nat. Commun."},{"key":"boe-14-7-3584-R30","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1152\/jn.00424.2011","volume":"107","author":"Albert","year":"2012","journal-title":"J. Neurophysiol."},{"key":"boe-14-7-3584-R31","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1152\/jn.00740.2017","volume":"120","author":"Barrett","year":"2018","journal-title":"J. Neurophysiol."},{"key":"boe-14-7-3584-R32","doi-asserted-by":"publisher","first-page":"5133","DOI":"10.3390\/s21155133","volume":"21","author":"Xu","year":"2021","journal-title":"Sensors"},{"key":"boe-14-7-3584-R34","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/s41593-019-0422-3","volume":"22","author":"Owen","year":"2019","journal-title":"Nat. Neurosci."}],"container-title":["Biomedical Optics Express"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=boe-14-7-3584&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:32:12Z","timestamp":1722958332000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=boe-14-7-3584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1364\/boe.494620","relation":{},"ISSN":["2156-7085","2156-7085"],"issn-type":[{"value":"2156-7085","type":"print"},{"value":"2156-7085","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/BOE.494620","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"research-article","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"2 May 2023","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"13 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"23 June 2023","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement","name":"copyright","label":"Copyright"}]}}