{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:37:38Z","timestamp":1785404258646,"version":"3.56.0"},"reference-count":40,"publisher":"Optica Publishing Group","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61975030"],"award-info":[{"award-number":["61975030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2021A1515011981"],"award-info":[{"award-number":["2021A1515011981"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2019ZT08Y105"],"award-info":[{"award-number":["2019ZT08Y105"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Eye Intelligent Medical Imaging Equipment Engineering Technology Research Center","award":["2022E076"],"award-info":[{"award-number":["2022E076"]}]},{"name":"Guangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory","award":["2020B1212030010"],"award-info":[{"award-number":["2020B1212030010"]}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY07551"],"award-info":[{"award-number":["P30EY07551"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY022362"],"award-info":[{"award-number":["R01EY022362"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY022362"],"award-info":[{"award-number":["R01EY022362"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p>\n                    Microliter air-pulse optical coherence elastography (OCE) has recently been proposed for the characterization of soft-tissue biomechanics using transient, sub-nanometer to micrometer-scale natural frequency oscillations. However, previous studies have not been able to provide real-time air-pulse monitoring during OCE natural frequency measurement, which could lead to inaccurate measurement results due to the unknown excitation spectrum. To address this issue, we introduce a dual-channel air-pulse OCE method, with one channel stimulating the sample and the other being simultaneously measured with a pressure sensor. This allows for more accurate natural frequency characterization using the frequency response function, as proven by a comprehensive comparison under different conditions with a diverse range of excitation spectra (from broad to narrow, clean to noisy) as well as a diverse set of sample response spectra. We also demonstrate the capability of the frequency-response analysis in distinguishing samples with different stiffness levels: the dominant natural frequencies increased with agar concentrations (181\u2013359\u2005Hz, concentrations: 1\u20132%, and maximum displacements: 0.12\u20130.47 \u00b5m) and intraocular pressures (IOPs) for the silicone cornea (333\u2013412\u2005Hz, IOP: 5\u201340 mmHg, and maximum displacements: 0.41\u20130.52 \u00b5m) under a 200\u2005Pa stimulation pressure. These frequencies remained consistent across different air-pulse durations (3\u2005ms to 35\u2005ms). The dual-channel OCE approach that uses transient, low-pressure stimulation and high-resolution imaging holds the potential to advance our understanding of sample frequency responses, especially when investigating delicate tissues such as the human cornea\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1364\/boe.520551","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:00:07Z","timestamp":1713337207000},"page":"3301","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dual-channel air-pulse optical coherence elastography for frequency-response analysis"],"prefix":"10.1364","volume":"15","author":[{"given":"Chengjin","family":"Song","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xvvvp28","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"He","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xvvvp28","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Engineering and Technology, Hubei University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-5153","authenticated-orcid":true,"given":"Michael D.","family":"Twa","sequence":"additional","affiliation":[{"name":"University of Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Huang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xvvvp28","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guangdong Weiren Meditech Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-5791","authenticated-orcid":true,"given":"Jingjiang","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xvvvp28","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guangdong Weiren Meditech Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangdong Weiren Meditech Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"An","sequence":"additional","affiliation":[{"name":"Guangdong Weiren Meditech Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University"},{"name":"Institute of Medical Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6928-2398","authenticated-orcid":true,"given":"Gongpu","family":"Lan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xvvvp28","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guangdong Weiren Meditech Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"boe-15-5-3301-R1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/s41592-018-0015-1","volume":"15","author":"Wu","year":"2018","journal-title":"Nat. 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