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Opt. Express"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>The early stage of dental caries, i.e. demineralization, has always been a topic of concern to dentists. Understanding the essential mechanism of its occurrence is of great significance for the prevention and treatment of dental caries. However, owing to limitations in resolution and the detection capabilities of diagnostic tools, the study of enamel demineralization has always been a challenge. Terahertz (THz) technology, especially the combination of scanning near-field optical microscopy (s-SNOM) and THz time-domain spectroscopy (TDS), due to its nanoscale resolution, has shown great advantages in the field of biological imaging. Here, a THz s-SNOM system is used to perform near-field imaging of enamel before and after demineralization at the nanoscale. It can be found that near-field signals decrease significantly after demineralization. This is due to the changes of the crystal lattice and the transfer of mineral ions during demineralization, which leads to a decrease in the permittivity of the enamel. The novel approach in this study reveals the essence of demineralization and lays the groundwork for additional research and potential interventions.<\/jats:p>","DOI":"10.1364\/boe.527554","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T04:00:21Z","timestamp":1723003221000},"page":"5229","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling enamel demineralization mechanisms by sensitive dielectric differentiation based on terahertz nanospectroscopy"],"prefix":"10.1364","volume":"15","author":[{"given":"Feng","family":"Xiao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiuyan","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Tang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Yin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Hu","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-4147","authenticated-orcid":true,"given":"Min","family":"Hu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Laboratory of Terahertz Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"boe-15-9-5229-R1","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1038\/s41467-019-12185-7","volume":"10","author":"Beniash","year":"2019","journal-title":"Nat. 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