{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:42:49Z","timestamp":1788507769241,"version":"build-2803163510"},"reference-count":48,"publisher":"Optica Publishing Group","issue":"9","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1934977"],"award-info":[{"award-number":["1934977"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>Early virus identification is a key component of both patient treatment\n\t\t\t\t\tand epidemiological monitoring. In the case of influenza A virus\n\t\t\t\t\tinfections, where the detection of subtypes associated with bird flu\n\t\t\t\t\tin humans could lead to a pandemic, rapid subtype-level identification\n\t\t\t\t\tis important. Surface-enhanced Raman spectroscopy coupled with machine\n\t\t\t\t\tlearning can be used to rapidly detect and identify viruses in a\n\t\t\t\t\tlabel-free manner. As there is a range of available excitation\n\t\t\t\t\twavelengths for performing Raman spectroscopy, we must choose the best\n\t\t\t\t\tone to permit discrimination between highly similar subtypes of a\n\t\t\t\t\tvirus. We show that the spectra produced by influenza A subtypes H1N1\n\t\t\t\t\tand H3N2 exhibit a higher degree of dissimilarity when using\n\t\t\t\t\t785\u2005nm excitation wavelength in comparison with 532\u2005nm\n\t\t\t\t\texcitation wavelength. Furthermore, the cross-validated area under the\n\t\t\t\t\tcurve (AUC) for identification was higher for the 785\u2005nm\n\t\t\t\t\texcitation, reaching 0.95 as compared to 0.86 for 532\u2005nm.\n\t\t\t\t\tUltimately, this study suggests that exciting with a 785\u2005nm\n\t\t\t\t\twavelength is better able to differentiate two closely related\n\t\t\t\t\tinfluenza viruses and likely can extend to other closely related\n\t\t\t\t\tpathogens.<\/jats:p>","DOI":"10.1364\/boe.533457","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:00:29Z","timestamp":1721386829000},"page":"5081","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rapid and label-free influenza A virus subtyping using surface-enhanced Raman spectroscopy with incident-wavelength analysis"],"prefix":"10.1364","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-1112","authenticated-orcid":true,"given":"RyeAnne","family":"Ricker","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Perea Lopez","sequence":"additional","affiliation":[{"name":"Pennsylvania State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Terrones","sequence":"additional","affiliation":[{"name":"Pennsylvania State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Loew","sequence":"additional","affiliation":[{"name":"George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Ghedin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"boe-15-9-5081-R1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/jmv.25674","volume":"92","author":"Zhang","year":"2020","journal-title":"J. Med.\n\t\t\t\t\tVirol."},{"key":"boe-15-9-5081-R2","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cmi.2017.11.018","volume":"24","author":"Huang","year":"2018","journal-title":"Clin. Microbiol.\n\t\t\t\t\tInfect."},{"key":"boe-15-9-5081-R3","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1128\/JCM.36.10.2990-2995.1998","volume":"36","author":"Stockton","year":"1998","journal-title":"J Clin Microbiol"},{"key":"boe-15-9-5081-R4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s12276-021-00603-0","volume":"53","author":"Harrington","year":"2021","journal-title":"Experimental & Molecular Medicine"},{"key":"boe-15-9-5081-R5","doi-asserted-by":"publisher","first-page":"a038778","DOI":"10.1101\/cshperspect.a038778","volume":"10","author":"Wu","year":"2020","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"boe-15-9-5081-R6","doi-asserted-by":"publisher","first-page":"2223057","DOI":"10.1080\/21505594.2023.2223057","volume":"14","author":"Liang","year":"2023","journal-title":"Virulence"},{"key":"boe-15-9-5081-R7","doi-asserted-by":"publisher","first-page":"11593","DOI":"10.1039\/D1NR00708D","volume":"13","author":"Tahir","year":"2021","journal-title":"Nanoscale"},{"key":"boe-15-9-5081-R8","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nprot.2016.036","volume":"11","author":"Butler","year":"2016","journal-title":"Nat\n\t\t\t\t\tProtoc"},{"key":"boe-15-9-5081-R9","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.1021\/acs.chemrev.7b00668","volume":"118","author":"Zong","year":"2018","journal-title":"Chem. Rev."},{"key":"boe-15-9-5081-R10","doi-asserted-by":"publisher","first-page":"20160037","DOI":"10.1515\/revac-2016-0037","volume":"36","author":"Nguyen","year":"2017","journal-title":"Rev Anal Chem"},{"key":"boe-15-9-5081-R11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1267\/ahc.18019","volume":"51","author":"Kumamoto","year":"2018","journal-title":"Acta Histochem\n\t\t\t\t\tCytochem"},{"key":"boe-15-9-5081-R12","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1002\/bio.4383","volume":"37","author":"Wang","year":"2022","journal-title":"Luminescence"},{"key":"boe-15-9-5081-R13","doi-asserted-by":"publisher","first-page":"e2118836119","DOI":"10.1073\/pnas.2118836119","volume":"119","author":"Ye","year":"2022","journal-title":"Proc. Natl. Acad. Sci.\n\t\t\t\t\tU.S.A."},{"key":"boe-15-9-5081-R14","doi-asserted-by":"publisher","first-page":"123087","DOI":"10.1016\/j.saa.2023.123087","volume":"302","author":"Lv","year":"2023","journal-title":"Spectrochim. Acta, Part A"},{"key":"boe-15-9-5081-R15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.pdpdt.2019.08.006","volume":"28","author":"Tong","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"boe-15-9-5081-R16","doi-asserted-by":"publisher","first-page":"112436","DOI":"10.1016\/j.bios.2020.112436","volume":"166","author":"Vermisoglou","year":"2020","journal-title":"Biosens.\n\t\t\t\t\tBioelectron."},{"key":"boe-15-9-5081-R17","doi-asserted-by":"publisher","first-page":"116738","DOI":"10.1016\/j.trac.2022.116738","volume":"157","author":"Lou","year":"2022","journal-title":"TrAC, Trends Anal.\n\t\t\t\t\tChem."},{"key":"boe-15-9-5081-R18","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/jrs.4581","volume":"45","author":"Synytsya","year":"2014","journal-title":"J. Raman\n\t\t\t\t\tSpectrosc."},{"key":"boe-15-9-5081-R19","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.3390\/s100301871","volume":"10","author":"Downes","year":"2010","journal-title":"Sensors"},{"key":"boe-15-9-5081-R20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/bkcs.11914","volume":"41","author":"Park","year":"2020","journal-title":"Bull.\n\t\t\t\t\tKorean Chem. Soc."},{"key":"boe-15-9-5081-R21","first-page":"18","volume":"34","author":"Schie","year":"2019","journal-title":"Spectroscopy Supplements"},{"key":"boe-15-9-5081-R22","doi-asserted-by":"publisher","first-page":"D49","DOI":"10.1016\/j.vaccine.2008.07.039","volume":"26","author":"Bouvier","year":"2008","journal-title":"Vaccine"},{"key":"boe-15-9-5081-R23","doi-asserted-by":"publisher","first-page":"114905","DOI":"10.1016\/j.jviromet.2024.114905","volume":"326","author":"Perea Lopez","year":"2024","journal-title":"J. Virol.\n\t\t\t\t\tMethods"},{"key":"boe-15-9-5081-R24","doi-asserted-by":"publisher","first-page":"e1601026","DOI":"10.1126\/sciadv.1601026","volume":"2","author":"Yeh","year":"2016","journal-title":"Sci. Adv."},{"key":"boe-15-9-5081-R25","doi-asserted-by":"publisher","first-page":"790323","DOI":"10.1155\/2013\/790323","volume":"2013","author":"Hong","year":"2013","journal-title":"J. Nanomater."},{"key":"boe-15-9-5081-R26","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1021\/acsphotonics.2c00456","volume":"9","author":"Zhang","year":"2022","journal-title":"ACS Photonics"},{"key":"boe-15-9-5081-R27","doi-asserted-by":"publisher","first-page":"095301","DOI":"10.1088\/0957-4484\/23\/9\/095301","volume":"23","author":"Seol","year":"2012","journal-title":"Nanotechnology"},{"key":"boe-15-9-5081-R30","doi-asserted-by":"publisher","author":"Ricker","year":"2024","DOI":"10.5281\/zenodo.11582348"},{"key":"boe-15-9-5081-R31","unstructured":"Ricker R. , \u201c Virus Detection Raman Wavelength Comparison ,\u201d GitHub , 2024 , https:\/\/github.com\/GhedinSGS\/Virus_Detection_Raman_Wavelength_Comparison ."},{"key":"boe-15-9-5081-R32","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1364\/BOE.476507","volume":"13","author":"Wahl","year":"2022","journal-title":"Biomed. Opt.\n\t\t\t\t\tExpress"},{"key":"boe-15-9-5081-R33","doi-asserted-by":"publisher","first-page":"e202000456","DOI":"10.1002\/jbio.202000456","volume":"14","author":"Song","year":"2021","journal-title":"J.\n\t\t\t\t\tBiophotonics"},{"key":"boe-15-9-5081-R35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"boe-15-9-5081-R37","first-page":"2825","volume":"12","author":"Pedregosa","year":"2011","journal-title":"Journal of\n\t\t\t\t\tMachine Learning Research"},{"key":"boe-15-9-5081-R38","first-page":"627","volume":"4","author":"Hajian-Tilaki","year":"2013","journal-title":"Caspian J Intern\n\t\t\t\t\tMed"},{"key":"boe-15-9-5081-R39","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1021\/acs.jctc.0c00126","volume":"16","author":"Henschel","year":"2020","journal-title":"J. Chem. Theory Comput."},{"key":"boe-15-9-5081-R40","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/opo.12131","volume":"34","author":"Armstrong","year":"2014","journal-title":"Ophthalmic\n\t\t\t\t\tPhysiol Opt"},{"key":"boe-15-9-5081-R42","doi-asserted-by":"publisher","first-page":"5146","DOI":"10.1002\/jcp.29392","volume":"235","author":"Pezzotti","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"boe-15-9-5081-R44","doi-asserted-by":"publisher","first-page":"114721","DOI":"10.1016\/j.bios.2022.114721","volume":"217","author":"Yang","year":"2022","journal-title":"Biosens.\n\t\t\t\t\tBioelectron."},{"key":"boe-15-9-5081-R45","doi-asserted-by":"publisher","first-page":"15567","DOI":"10.3390\/ijms242115567","volume":"24","author":"Pezzotti","year":"2023","journal-title":"Int. J.\n\t\t\t\t\tMol. Sci."},{"key":"boe-15-9-5081-R46","doi-asserted-by":"publisher","first-page":"99","DOI":"10.4103\/IJPSYM.IJPSYM_499_18","volume":"41","author":"Andrade","year":"2019","journal-title":"Indian J Psychol Med"},{"key":"boe-15-9-5081-R47","first-page":"39","volume":"35","author":"Schultz","year":"2020","journal-title":"Spectroscopy"},{"key":"boe-15-9-5081-R49","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.1093\/bioinformatics\/bty373","volume":"34","author":"Nembrini","year":"2018","journal-title":"Bioinformatics"},{"key":"boe-15-9-5081-R50","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.3390\/cells10071722","volume":"10","author":"Moreira","year":"2021","journal-title":"Cells"},{"key":"boe-15-9-5081-R51","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1038\/s41467-019-12898-9","volume":"10","author":"Ho","year":"2019","journal-title":"Nat. Commun."},{"key":"boe-15-9-5081-R52","doi-asserted-by":"publisher","first-page":"e13114","DOI":"10.1111\/irv.13114","volume":"17","author":"Wang","year":"2023","journal-title":"Influenza Other Respir. Viruses"},{"key":"boe-15-9-5081-R53","doi-asserted-by":"publisher","first-page":"129196","DOI":"10.1016\/j.snb.2020.129196","volume":"329","author":"Liu","year":"2021","journal-title":"Sens.\n\t\t\t\t\tActuators, B"},{"key":"boe-15-9-5081-R54","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.3390\/bios12121065","volume":"12","author":"Tabarov","year":"2022","journal-title":"Biosensors"},{"key":"boe-15-9-5081-R56","doi-asserted-by":"publisher","first-page":"115202","DOI":"10.1016\/j.bios.2023.115202","volume":"228","author":"Park","year":"2023","journal-title":"Biosens. Bioelectron."}],"container-title":["Biomedical Optics Express"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=boe-15-9-5081","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=boe-15-9-5081&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:29:31Z","timestamp":1723030171000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=boe-15-9-5081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":48,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024]]},"published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1364\/boe.533457","relation":{},"ISSN":["2156-7085","2156-7085"],"issn-type":[{"value":"2156-7085","type":"print"},{"value":"2156-7085","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/BOE.533457","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"research-article","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"20 June 2024","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"18 July 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"7 August 2024","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2024 Optica Publishing Group under the terms\n\t\t\t\t\tof the Optica Open\n\t\t\t\t\tAccess Publishing Agreement","name":"copyright","label":"Copyright"}]}}