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Opt. Express"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>The influence of hypoxia - a condition where tissues are under oxygen deficiency - on the human brain under functional load has not been fully understood yet. This study aims to analyse the effects of hypoxia on the brain\u2019s haemodynamic response under visual stimulation, using the in-house developed functional near-infrared spectroscopy system and to quantify the hemodynamic response. Our results (median, 25<jats:sup>th<\/jats:sup> and 75<jats:sup>th<\/jats:sup> percentile) demonstrate the amplitude of the oxygenated haemoglobin functional response during hypoxia 0.30 \u00b5M (0.27, 0.41) was lower compared with the normoxia 0.63 \u00b5M (0.54, 0.93) and hyperoxia 0.73 \u00b5M (0.43, 1.09). No statistical significance is observed for the deoxygenated haemoglobin changes. The hypoxia has a statistically significant effect on the amplitude of the haemodynamic response (p\u2009&lt;\u20090.001).<\/jats:p>","DOI":"10.1364\/boe.545722","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T16:00:31Z","timestamp":1737993631000},"page":"1457","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxygen-dependent functional brain haemodynamic response"],"prefix":"10.1364","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3711-9411","authenticated-orcid":true,"given":"Karolina","family":"Bejm","sequence":"first","affiliation":[{"name":"Polish Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-4730","authenticated-orcid":true,"given":"Stanislaw","family":"Wojtkiewicz","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zanna","family":"Pastuszak","sequence":"additional","affiliation":[{"name":"Mossakowski Medical Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-7568","authenticated-orcid":true,"given":"Adam","family":"Liebert","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"285","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"boe-16-4-1457-R1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13231-016-0023-0","volume":"8","author":"Ferdinand","year":"2016","journal-title":"Exp. & Trans. 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Further distribution of this work must maintain attribution to the author(s) and the published article\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}