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In the glaucoma model, the intensity of the ganglion cell layer relative to the internal limiting membrane was reduced. Both disease models exhibited decreased retinal arteriovenous and total blood flow, increased venous oxygen saturation, and a reduced arteriovenous oxygen saturation difference. We also compared the visible light OCT system with an 840 nm spectral domain OCT and a 1060 nm swept source OCT for mouse retinal imaging. The visualization and monitoring of retinal function and metabolic capacity using mouse models through visible light OCT may provide new opportunities for understanding the pathology of ocular diseases.<\/jats:p>","DOI":"10.1364\/boe.551561","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T06:01:35Z","timestamp":1744092095000},"page":"2077","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Visible light optical coherence tomography for assessing retinal structure and function in diseased mouse models"],"prefix":"10.1364","volume":"16","author":[{"given":"Qianyue","family":"Gu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xiu","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songzhi","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-2687","authenticated-orcid":true,"given":"Kaiwen","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihan","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfei","family":"Tang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Yan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Eve Hospital Affiliated to Shanxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"He","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lu","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-5699","authenticated-orcid":true,"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"boe-16-5-2077-R1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","volume":"9","author":"London","year":"2013","journal-title":"Nat. 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