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Richardson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>In cataract surgery, the opacified crystalline lens is replaced by an artificial intraocular lens (IOL), requiring precise preoperative selection of parameters to optimize postoperative visual quality. Three-dimensional customized eye models, which can be constructed using quantitative data from anterior segment optical coherence tomography, provide a robust platform for virtual surgery. These models enable simulations and predictions of the optical outcomes for specific patients and selected IOLs. A critical step in building these models is estimating the IOL\u2019s tilt and position preoperatively based on the available preoperative geometrical information (ocular parameters). In this study, we present a machine learning model that, for the first time, incorporates the full shape geometry of the crystalline lens as candidate input features to predict the postoperative IOL tilt. Furthermore, we identify the most relevant features for this prediction task. Our model demonstrates statistically significantly lower estimation errors compared to a simple linear correlation method, reducing the estimation error by approximately 6%. These findings highlight the potential of this approach to enhance the accuracy of postoperative predictions. Further work is needed to examine the potential for such postoperative predictions to improve visual outcomes in cataract patients.<\/jats:p>","DOI":"10.1364\/boe.551733","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T04:00:11Z","timestamp":1740369611000},"page":"1439","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Postoperative intraocular lens tilt from preoperative full crystalline lens geometry using machine learning"],"prefix":"10.1364","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-8846","authenticated-orcid":true,"given":"Eduardo","family":"Martinez-Enriquez","sequence":"first","affiliation":[{"name":"Instituto de Optica Daza de Valdes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-7193","authenticated-orcid":true,"given":"Gonzalo","family":"Velarde-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital"},{"name":"Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Alejandre-Alba","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital"},{"name":"Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Ansah","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu","family":"Kishore","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto de Optica Daza de Valdes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-3206","authenticated-orcid":true,"given":"Ramya","family":"Natarajan","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute"},{"name":"L V Prasad Eye Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Vaddavalli","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute"},{"name":"L V Prasad Eye Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph O.","family":"Okudolo","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan B.","family":"McBee","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Celik","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujdat","family":"Cetin","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Lim","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Donald","family":"Koch","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"MacRae","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-1697","authenticated-orcid":true,"given":"Susana","family":"Marcos","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"boe-16-4-1439-R1","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.jcrs.2009.01.020","volume":"35","author":"Read","year":"2009","journal-title":"J. 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