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By incorporating a self-attention mechanism and a topology-preserving loss function, the method enhanced the signal-to-noise ratio and continuity of neuronal fibers. Applied to the three-dimensional reconstruction of complex fiber structures, it significantly improved the performance of existing algorithms, offering an effective technical approach for precise neuronal fiber structure analysis.<\/jats:p>","DOI":"10.1364\/boe.562737","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:59:58Z","timestamp":1747763998000},"page":"2584","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Image enhancement network based on fiber topology-preserving multi-module fusion for neuron reconstruction"],"prefix":"10.1364","volume":"16","author":[{"given":"Wu","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Liao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengda","family":"Bao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyi","family":"Sun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-6248","authenticated-orcid":true,"given":"Hui","family":"Gong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]},{"name":"HUST-Suzhou Institute for Brainsmatics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-6810","authenticated-orcid":true,"given":"Chi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Hainan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-4813","authenticated-orcid":true,"given":"Anan","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"publisher"}]},{"name":"HUST-Suzhou Institute for Brainsmatics"},{"name":"Hainan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"boe-16-7-2584-R1","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.neuron.2014.08.055","volume":"83","author":"Mitra","year":"2014","journal-title":"Neuron"},{"key":"boe-16-7-2584-R2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/nmeth.2477","volume":"10","author":"Osten","year":"2013","journal-title":"Nat. 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