{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:18:04Z","timestamp":1787044684836,"version":"build-2736575974"},"reference-count":50,"publisher":"Optica Publishing Group","issue":"8","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["Maestro 2023\/50\/A\/ST7\/00267"],"award-info":[{"award-number":["Maestro 2023\/50\/A\/ST7\/00267"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"publisher","award":["Profesura NAWA BPN\/PRO\/2022\/1\/00003"],"award-info":[{"award-number":["Profesura NAWA BPN\/PRO\/2022\/1\/00003"]}],"id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>\n                    Prostate cancer is a significant global health issue. To advance diagnostic and treatment procedures, such as image-guided needle biopsy, optical imaging methods offering high spatial resolution have been proposed. Optical coherence tomography (OCT) allows for detailed visualization of prostate microarchitecture in three dimensions; however, it does not reliably differentiate tumors from surrounding healthy tissue. In this study, we use wide-field quantitative micro-elastography (QME) to image the micro-scale mechanical properties of freshly excised human prostate to provide additional contrast of tumor, which is known to exhibit increased stiffness. In our approach, we generate volumetric OCT, strain, and elasticity images over a field-of-view (\n                    <jats:italic>x<\/jats:italic>\n                    \u2009\u00d7\u2009\n                    <jats:italic>y<\/jats:italic>\n                    \u2009\u00d7\u2009\n                    <jats:italic>z<\/jats:italic>\n                    ) of 46\u2009\u00d7\u200946\u2009\u00d7\u20091 mm\n                    <jats:sup>3<\/jats:sup>\n                    . We validate the contrast obtained in our images through co-registration with standard histology images.\n                  <\/jats:p>","DOI":"10.1364\/boe.563310","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T03:59:31Z","timestamp":1749700771000},"page":"3027","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Wide-field quantitative micro-elastography of freshly excised human prostate"],"prefix":"10.1364","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-5824","authenticated-orcid":true,"given":"Szymon","family":"Tamborski","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0102mm775","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-9595","authenticated-orcid":true,"given":"Marta K.","family":"Skrok","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0102mm775","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-4478","authenticated-orcid":true,"given":"Matt S.","family":"Hepburn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0102mm775","id-type":"ROR","asserted-by":"publisher"}]},{"name":"The University of Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Maniewski","sequence":"additional","affiliation":[{"name":"Nicolaus Copernicus University in Toru\u0144"},{"name":"Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Zdrenka","sequence":"additional","affiliation":[{"name":"Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital"},{"name":"Bydgoszcz University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Szylberg","sequence":"additional","affiliation":[{"name":"Nicolaus Copernicus University in Toru\u0144"},{"name":"Oncology Centre Prof. Franciszek \u0141ukaszczyk Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan F.","family":"Kennedy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0102mm775","id-type":"ROR","asserted-by":"publisher"}]},{"name":"The University of Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"boe-16-8-3027-R2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.euo.2023.12.007","volume":"7","author":"Corsini","year":"2024","journal-title":"European Urology Oncology"},{"key":"boe-16-8-3027-R3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.5489\/cuaj.1248","volume":"7","author":"Serefoglu","year":"2013","journal-title":"Can. Urol. Assoc. J."},{"key":"boe-16-8-3027-R4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.rcl.2023.06.014","volume":"62","author":"Dias","year":"2024","journal-title":"Radiologic Clinics of North America"},{"key":"boe-16-8-3027-R5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/17434440.2020.1755258","volume":"17","author":"Napoli","year":"2020","journal-title":"Expert Rev. Med. Devices"},{"key":"boe-16-8-3027-R6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s10334-022-01006-6","volume":"35","author":"Fernandes","year":"2022","journal-title":"Magn. Reson. Mater. Phy."},{"key":"boe-16-8-3027-R7","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1007\/s00261-019-02391-8","volume":"45","author":"Das","year":"2020","journal-title":"Abdom. Radiol."},{"key":"boe-16-8-3027-R8","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1007\/s00261-024-04423-4","volume":"49","author":"Correia","year":"2024","journal-title":"Abdominal Radiology"},{"key":"boe-16-8-3027-R9","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1148\/radiol.2021204459","volume":"302","author":"Chatterjee","year":"2022","journal-title":"Radiology"},{"key":"boe-16-8-3027-R10","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1002\/mrm.29264","volume":"88","author":"Lo","year":"2022","journal-title":"Magn. Reson. Med."},{"key":"boe-16-8-3027-R11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/jmri.25419","volume":"45","author":"Brunsing","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"boe-16-8-3027-R12","doi-asserted-by":"publisher","first-page":"104225","DOI":"10.1016\/j.pdpdt.2024.104225","volume":"47","author":"Tajaldeen","year":"2024","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"boe-16-8-3027-R13","doi-asserted-by":"publisher","first-page":"e202200382","DOI":"10.1002\/jbio.202200382","volume":"16","author":"Gomes","year":"2023","journal-title":"J. Biophotonics"},{"key":"boe-16-8-3027-R14","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.3390\/cancers14061535","volume":"14","author":"Gaba","year":"2022","journal-title":"Cancers"},{"key":"boe-16-8-3027-R15","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s42003-023-04536-4","volume":"6","author":"Schueth","year":"2023","journal-title":"Commun. Biol."},{"key":"boe-16-8-3027-R16","author":"Drexler","year":"2015"},{"key":"boe-16-8-3027-R17","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0090-4295(00)00475-1","volume":"55","author":"D\u2019Amico","year":"2000","journal-title":"Urology"},{"key":"boe-16-8-3027-R18","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1590\/S1677-55382009000300011","volume":"35","author":"Dangle","year":"2009","journal-title":"Int. Braz. J. Urol."},{"key":"boe-16-8-3027-R19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.5858\/arpa.2018-0135-OA","volume":"143","author":"Gardecki","year":"2019","journal-title":"Arch. Pathol. Lab Med."},{"key":"boe-16-8-3027-R20","doi-asserted-by":"publisher","first-page":"037501","DOI":"10.1117\/1.JMI.2.3.037501","volume":"2","author":"Muller","year":"2015","journal-title":"J. Med. Imag."},{"key":"boe-16-8-3027-R21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/lsm.23093","volume":"51","author":"Swaan","year":"2019","journal-title":"Lasers Surg. Med."},{"key":"boe-16-8-3027-R22","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1364\/BOE.537783","volume":"15","author":"Skrok","year":"2024","journal-title":"Biomed. Opt. Express"},{"key":"boe-16-8-3027-R23","doi-asserted-by":"publisher","first-page":"e201800274","DOI":"10.1002\/jbio.201800274","volume":"12","author":"Swaan","year":"2019","journal-title":"J. Biophotonics"},{"key":"boe-16-8-3027-R24","first-page":"292","article-title":"Prostate Cancer: Diagnosis and Treatment","author":"Szyma\u0144skaBoffetta","year":"2019"},{"key":"boe-16-8-3027-R25","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1038\/s41598-024-53440-2","volume":"14","author":"Almalki","year":"2024","journal-title":"Sci. Rep."},{"key":"boe-16-8-3027-R26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nphoton.2017.6","volume":"11","author":"Kennedy","year":"2017","journal-title":"Nat. Photonics"},{"key":"boe-16-8-3027-R27","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1364\/BOE.8.001172","volume":"8","author":"Larin","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"boe-16-8-3027-R28","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3390\/diagnostics10120994","volume":"10","author":"Gubarkova","year":"2020","journal-title":"Diagnostics"},{"key":"boe-16-8-3027-R29","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1158\/0008-5472.CAN-19-1240","volume":"80","author":"Kennedy","year":"2020","journal-title":"Cancer Res."},{"key":"boe-16-8-3027-R30","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.1158\/0008-5472.CAN-22-0578","volume":"82","author":"Gong","year":"2022","journal-title":"Cancer Res."},{"key":"boe-16-8-3027-R31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.canlet.2014.11.021","volume":"357","author":"Li","year":"2015","journal-title":"Cancer Lett."},{"key":"boe-16-8-3027-R32","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/labinvest.2017.132","volume":"98","author":"Yuting","year":"2018","journal-title":"Lab Invest."},{"key":"boe-16-8-3027-R33","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.jbiomech.2016.02.013","volume":"49","author":"Ling","year":"2016","journal-title":"J. Biomech."},{"key":"boe-16-8-3027-R34","doi-asserted-by":"publisher","first-page":"15538","DOI":"10.1038\/srep15538","volume":"5","author":"Kennedy","year":"2015","journal-title":"Sci. Rep."},{"key":"boe-16-8-3027-R35","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1364\/BOE.9.001082","volume":"9","author":"Allen","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"boe-16-8-3027-R36","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1364\/BOE.447340","volume":"13","author":"Li","year":"2022","journal-title":"Biomed. Opt. Express"},{"key":"boe-16-8-3027-R37","doi-asserted-by":"publisher","first-page":"5127","DOI":"10.1364\/BOE.494013","volume":"14","author":"Metzner","year":"2023","journal-title":"Biomed. Opt. Express"},{"key":"boe-16-8-3027-R38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/modpathol.2017.133","volume":"31","author":"Epstein","year":"2018","journal-title":"Mod. Pathol."},{"key":"boe-16-8-3027-R39","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3348\/kjr.2014.15.3.346","volume":"15","author":"Woo","year":"2014","journal-title":"Korean J. Radiol."},{"key":"boe-16-8-3027-R40","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1158\/0008-5472.CAN-14-3694","volume":"75","author":"Kennedy","year":"2015","journal-title":"Cancer Res."},{"key":"boe-16-8-3027-R41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/JSTQE.2018.2871596","volume":"25","author":"Wijesinghe","year":"2019","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"boe-16-8-3027-R42","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41467-017-00460-4","volume":"8","author":"Tyekucheva","year":"2017","journal-title":"Nat. Commun."},{"key":"boe-16-8-3027-R43","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1038\/ijir.2008.55","volume":"20","author":"Roehrborn","year":"2008","journal-title":"Int. J. Impot. Res."},{"key":"boe-16-8-3027-R44","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.juro.2014.09.100","volume":"193","author":"Boehm","year":"2015","journal-title":"J. Urol."},{"key":"boe-16-8-3027-R45","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ultrasmedbio.2020.10.018","volume":"47","author":"Dai","year":"2021","journal-title":"Ultrasound in Medicine & Biology"},{"key":"boe-16-8-3027-R46","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1038\/s41598-017-02187-0","volume":"7","author":"Sang","year":"2017","journal-title":"Sci. Rep."},{"key":"boe-16-8-3027-R47","doi-asserted-by":"publisher","first-page":"20180970","DOI":"10.1259\/bjr.20180970","volume":"92","author":"Ji","year":"2009","journal-title":"Br. J. Radiol."},{"key":"boe-16-8-3027-R48","doi-asserted-by":"publisher","first-page":"121510","DOI":"10.1117\/1.JBO.18.12.121510","volume":"18","author":"Kennedy","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"boe-16-8-3027-R49","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1364\/OL.37.002310","volume":"37","author":"Kennedy","year":"2012","journal-title":"Opt. Lett."},{"key":"boe-16-8-3027-R50","article-title":"Tissue Processing","author":"Winsor","year":"1994"},{"key":"boe-16-8-3027-R51","doi-asserted-by":"publisher","first-page":"e41265","DOI":"10.1016\/j.heliyon.2024.e41265","volume":"11","author":"Sanderson","year":"2025","journal-title":"Heliyon"}],"updated-by":[{"DOI":"10.1364\/boe.614205","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000}}],"container-title":["Biomedical Optics Express"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=boe-16-8-3027&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T09:57:53Z","timestamp":1751536673000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=boe-16-8-3027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1364\/boe.563310","relation":{},"ISSN":["2156-7085","2156-7085"],"issn-type":[{"value":"2156-7085","type":"print"},{"value":"2156-7085","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/BOE.563310","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"research-article","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"25 March 2025","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"10 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"3 July 2025","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}