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We characterize how the remote refocusing performance at sample refractive indices up to\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091.5 can be partially compensated for using adjustment of the correction collar on the primary objective. We apply the system to imaging a range of biological samples with varied refractive indices. Combined with tiled acquisition, image stitching, and multi-view image fusion, the microscope enables multicolour imaging of mm-wide and \u223c250 \u00b5m thick optically cleared mouse ovarian cancer, bone marrow, and colon tissue samples, and a whole\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    fruit fly brain. 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Further distribution of this work must maintain attribution to the author(s) and the published article\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}