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However, 24-month-old mice are insensitive to both factors, PBM and its suppression by the NO blockade. In old mice, a decrease in sensitivity to PBM is associated with age-related lymphatic endothelium dysfunction, including changes in the cLV morphology (hyperplasia), a decrease in the NO production, and the contractility of cLVs, leading to reduced lymphatic removal of beta amyloid from the brain. These results suggest that the combined therapy, including PBM with an increase in NO production in the lymphatic endothelium, can substantially improve the effectiveness of the stimulating effects of PBM on brain drainage and the removal of toxic metabolites from its tissues, which might generally contribute to improving phototherapy of brain diseases in the elderly.<\/jats:p>","DOI":"10.1364\/boe.577347","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:00:11Z","timestamp":1761548411000},"page":"5118","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["NO-ergic mechanisms of age differences in photostimulation of lymphatic drainage, filtration, and clearance"],"prefix":"10.1364","volume":"16","author":[{"given":"Anastasiia","family":"Semyichkina-Glushkovskaia","sequence":"first","affiliation":[{"name":"Saratov State 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