{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:06:44Z","timestamp":1790644004352,"version":"4.1.0"},"reference-count":35,"publisher":"Optica Publishing Group","issue":"4","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62405022"],"award-info":[{"award-number":["62405022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Yunnan Fundamental Research Projects","award":["202502AS100004"],"award-info":[{"award-number":["202502AS100004"]}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>\n                    The diagnosis of gastrointestinal diseases requires effective structural and functional information, which also requires that the endoscope has excellent performance in terms of high resolution, a large field of view, and three-dimensional penetration depth. However, existing optical and electronic endoscopes are limited to superficial observation and are unable to capture information from deep tissues. Here, we propose a front-view MEMS-based optical coherence tomography (OCT) endoscopic probe with a diameter of 8\u2005mm, a lateral resolution of 25\u2005\u00b5m, an imaging field of view (FOV) of 4\u2009\u00d7\u20094 mm\n                    <jats:sup>2<\/jats:sup>\n                    , and a penetration depth of 2\u2005mm. Compared with previously reported MEMS-based OCT endoscopic probes, it allows front-view observation and a larger FOV. We utilized the probe to image the internal organs in mice and study the development and self-healing of the acute gastric ulcer. The findings indicate that during the development of a stomach ulcer, a distinct lesion can be visualized on OCT cross-sectional images, disrupting the integrity of the mucosal layer. During the self-healing of a gastric ulcer, the gastric septal tissue healed to a normal state, with recovery of stomach wall thickness and gradual disappearance of the ulcer area. Our work demonstrates that the MEMS-based OCT probe has potential for minimally invasive or non-invasive imaging and diagnosis of gastrointestinal diseases in the future.\n                  <\/jats:p>","DOI":"10.1364\/boe.590614","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:00:06Z","timestamp":1771570806000},"page":"1585","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MEMS-based large-field-of-view optical coherence tomography endoscopy for gastric ulcer imaging in mice"],"prefix":"10.1364","volume":"17","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifan","family":"Zhao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxiang","family":"Qi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Pu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxun","family":"Li","sequence":"additional","affiliation":[{"name":"Children's Hospital of Chongqing Medical University, Chongqing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Pa","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-0021","authenticated-orcid":true,"given":"Huikai","family":"Xie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01skt4w74","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"boe-17-4-1585-R1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrgastro.2017.53","type":"journal-article","volume":"14","author":"Padmanabhan","year":"2017","journal-title":"Nat. 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Hepatol."},{"key":"boe-17-4-1585-R5","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1053\/j.gastro.2023.05.050","type":"journal-article","volume":"165","author":"Wang","year":"2023","journal-title":"Gastroenterology"},{"key":"boe-17-4-1585-R6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrgastro.2013.80","type":"journal-article","volume":"10","author":"Bredenoord","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"boe-17-4-1585-R7","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nrgastro.2015.128","type":"journal-article","volume":"12","author":"Veitch","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"boe-17-4-1585-R8","doi-asserted-by":"publisher","first-page":"17390","DOI":"10.1038\/s41598-024-68430-7","type":"journal-article","volume":"14","author":"Mu","year":"2024","journal-title":"Sci. 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