{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:54:15Z","timestamp":1785405255434,"version":"3.56.0"},"reference-count":34,"publisher":"Optica Publishing Group","issue":"6","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["Grant no. 25-75-10082"],"award-info":[{"award-number":["Grant no. 25-75-10082"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    A critical challenge in endocrine neurosurgery is intraoperative discrimination between normal pituitary tissue and pituitary neuroendocrine tumors (PitNETs). Suggesting the universal persistence of near-infrared autofluorescence (NIRAF) in endocrine organs and inspired by routine clinical use of NIRAF for parathyroid gland identification, we discovered that pituitary NIRAF can be employed for label-free transsphenoidal surgery guidance.\n                    <jats:italic>Ex vivo<\/jats:italic>\n                    confocal spectral imaging of 33 specimens identified secretory granules as the dominant long-wavelength fluorescence source and showed that the normal pituitary had higher granule content than PitNETs. We made use of the pituitary NIRAF during surgery and assessed its performance for pituitary\/adenoma separation\n                    <jats:italic>in vivo<\/jats:italic>\n                    for 27 surgeries, and showed separability between pituitary and non-pituitary measurement sites with an ROC-AUC of 0.99. The obtained results clearly demonstrate that the suggested method, based on the solid microscopic background, has the potential for clinical translation and paves the way for enhanced gland preservation during resection.\n                  <\/jats:p>","DOI":"10.1364\/boe.597265","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:38:21Z","timestamp":1779809901000},"page":"3180","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR autofluorescence allows for pituitary gland detection during surgery: evidence from microscopic studies and in vivo measurements"],"prefix":"10.1364","volume":"17","author":[{"given":"Veronika","family":"Alibaeva","sequence":"first","affiliation":[{"name":"Lomonosov Moscow State University"},{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Korneva","sequence":"additional","affiliation":[{"name":"Lomonosov Moscow State University"},{"name":"Endocrinology Research Center"},{"name":"Sechenov First Moscow State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Grigoriev","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigoriy","family":"Starkov","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Budylin","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Yakimov","sequence":"additional","affiliation":[{"name":"Lomonosov Moscow State University"},{"name":"Sechenov First Moscow State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilen","family":"Azizyan","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Lapshina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nano","family":"Pachuashvili","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Troshina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya","family":"Urusova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Shirshin","sequence":"additional","affiliation":[{"name":"Lomonosov Moscow State University"},{"name":"Endocrinology Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"boe-17-6-3180-R1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s11604-023-01400-7","type":"journal-article","volume":"41","author":"Tsukamoto","year":"2023","journal-title":"Jpn. 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