{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:54:25Z","timestamp":1785405265017,"version":"3.56.0"},"reference-count":45,"publisher":"Optica Publishing Group","issue":"7","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    Blastocyst grading during\n                    <jats:italic>in vitro<\/jats:italic>\n                    fertilization relies on subjective morphology, motivating quantitative, label-free biomarkers measurable in blastocysts. We apply dynamic optical coherence microscopy (dOCM) to murine blastocysts and quantify intracellular fluctuation spectra using full- and band-resolved metrics (mean frequency, RMS bandwidth, motility amplitude, and variance fraction). Using cell counting as a benchmark, full-band metrics show no significant differences between low- and high-cell-count cohorts. In contrast, band-resolved analysis reveals higher mid-band mean frequency and increased mid-band RMS bandwidth in higher-cell-count embryos, accompanied by a significant decrease in low-frequency variance fraction. These exploratory results suggest frequency-specific dOCM signatures as candidate biomarkers for blastocyst quality.\n                  <\/jats:p>","DOI":"10.1364\/boe.599635","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:00:08Z","timestamp":1779703208000},"page":"3413","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Label-free candidate dOCM biomarkers associated with blastocyst quality using total cell count as a proxy"],"prefix":"10.1364","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-917X","authenticated-orcid":true,"given":"Yunqin","family":"Zhao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5230-954X","authenticated-orcid":true,"given":"Saanjali","family":"Majmundar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Vanderbilt University, Vanderbilt Institute for Surgery and Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Stoebner","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5412-3976","authenticated-orcid":true,"given":"Audrey K.","family":"Bowden","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vm5rt34","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"boe-17-7-3413-R1","first-page":"257","type":"journal-article","volume":"3","author":"Ombelet","year":"2011","journal-title":"Facts Views Vis. 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Further distribution of this work must maintain attribution to the author(s) and the published article\u2019s title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}