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The two-dimensional cross-coverage geometry with the 660\/904\u2005nm pair yielded the lowest total estimation uncertainty (\u03c3total\u2009=\u20090.0490 \u03bcM, cond(A)\u2009=\u20091.50) and remained stable under pathlength, noise-model, and fluence-cutoff perturbations. A geometry-defined motor-cortex region of interest on a public finger-tapping dataset provided pipeline validation, a Colin27 anatomical-atlas simulation supported the directional robustness of the geometry result, and a four-channel prototype demonstrated hardware feasibility. The principal contribution is a reproducible simulation\u2013statistics\u2013validation methodology; the 660\/904\u2005nm configuration is the framework\u2019s model-based prediction under the present tissue model, to be confirmed by future in-vivo wavelength comparison.<\/jats:p>","DOI":"10.1364\/boe.603153","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:00:09Z","timestamp":1785740409000},"page":"4568","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simulation-driven probe design and dual-wavelength optimization for wearable cerebral oxygenation monitoring"],"prefix":"10.1364","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6351-6411","authenticated-orcid":true,"given":"Lizheng","family":"Hou","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013x4kb81","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Pan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013x4kb81","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013x4kb81","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Zheng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/013x4kb81","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"boe-17-9-4568-R1","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1213\/ANE.0b013e31826dd6a6","type":"journal-article","volume":"115","author":"Ghosh","year":"2012","journal-title":"Anesth. 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