{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:20:20Z","timestamp":1785406820357,"version":"3.56.0"},"reference-count":43,"publisher":"Optica Publishing Group","issue":"3","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR-OA"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62375170"],"award-info":[{"award-number":["62375170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62535019"],"award-info":[{"award-number":["62535019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"crossref","award":["YG2024QNA51"],"award-info":[{"award-number":["YG2024QNA51"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["20DZ222040"],"award-info":[{"award-number":["20DZ222040"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/03kt66j61","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Opt. Express"],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:p>\n                    Infrared (IR) spectroscopy has emerged as a pivotal tool in biomedical diagnostics, offering label-free spectral biomarkers for the detection of numerous diseases, particularly in the fingerprint region. However, the lack of rapid and sensitive IR spectroscopic techniques for analyzing complex fluid analytes remains a critical challenge in clinical practice. To address this limitation, we present a metasurface-enhanced fingerprint infrared spectroscopic tool (ME-FIRST) that enhances light-matter interactions in sub-wavelength volumes through plasmonic resonances generated with a designed metasurface across the entire fingerprint range from 1900 cm\n                    <jats:sup>-1<\/jats:sup>\n                    to 1000\u2005cm\n                    <jats:sup>-1<\/jats:sup>\n                    . Numerical simulations reveal confined and enhanced electric near-field, with an average probing depth of \u223c100\u2005nm and an enhancement factor\n                    <jats:italic>\n                      |E\/E\n                      <jats:sub>0<\/jats:sub>\n                      |\n                    <\/jats:italic>\n                    of \u223c60-fold at resonant peaks. The ME-FIRST device is further experimentally fabricated and validated, and as a proof of concept, we demonstrate the sensing of molecular vibrational modes with a considerable sensitivity in\n                    <jats:italic>L<\/jats:italic>\n                    -lysine over the full fingerprint IR spectral range. The proposed ME-FIRST presents a promising platform for high-sensitivity IR spectroscopy of fluid analytes, paving the way for clinical applications of infrared spectroscopy in biofluid analysis and pathological scenarios.\n                  <\/jats:p>","DOI":"10.1364\/oe.584567","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:00:07Z","timestamp":1767884407000},"page":"4021","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ME-FIRST: a metasurface-enhanced fingerprint infrared spectroscopic tool for fluid analytes"],"prefix":"10.1364","volume":"34","author":[{"given":"Xiangyu","family":"Zhao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhu","family":"Shao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longsheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongzhao","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"oe-34-3-4021-R1","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1039\/C5CS00846H","type":"journal-article","volume":"45","author":"Pilling","year":"2016","journal-title":"Chem. 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