{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:10:11Z","timestamp":1790835011988,"version":"4.1.0"},"reference-count":21,"publisher":"Optica Publishing Group","issue":"9","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v1#VOR"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA213149"],"award-info":[{"award-number":["R01 CA213149"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB023232"],"award-info":[{"award-number":["R01 EB023232"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Opt. Lett."],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p>Defocus aberration in optical systems, including optical coherence tomography (OCT) systems employing Gaussian illumination, gives rise to the well-known compromise between transverse resolution and depth-of-field. This results in blurry images when out-of-focus, whilst other low-order aberrations (e.g.,\u00a0astigmatism, coma, etc.) present in both the OCT system and biological samples further reduce image resolution and contrast. Computational adaptive optics (CAO) is a computed optical interferometric imaging technique that modifies the phase of the OCT data in the spatial frequency domain to correct optical aberrations and provide improvement of the image quality throughout the three-dimensional (3D) volume. In this Letter, we report the first implementation of CAO for polarization-sensitive OCT to correct defocus and other low-order aberrations, providing enhanced polarization-sensitive imaging contrast (i.e.,\u00a0intensity and phase retardation) on a 3D OCT phantom, molded plastics, <jats:italic toggle=\"yes\">ex vivo<\/jats:italic> chicken breast tissue, and <jats:italic toggle=\"yes\">ex\u00a0vivo<\/jats:italic> human breast cancer tissue.<\/jats:p>","DOI":"10.1364\/ol.418637","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:00:24Z","timestamp":1616529624000},"page":"2071","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Computational adaptive optics for polarization-sensitive optical coherence tomography"],"prefix":"10.1364","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-181X","authenticated-orcid":true,"given":"Jianfeng","family":"Wang","sequence":"first","affiliation":[{"name":"University of Illinois at Urbana-Champaign"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Chaney","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana-Champaign"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edita","family":"Aksamitiene","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana-Champaign"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Marjanovic","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana-Champaign"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-5630","authenticated-orcid":true,"given":"Stephen A.","family":"Boppart","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana-Champaign"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ol-46-9-2071-R1","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1126\/science.1957169","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"ol-46-9-2071-R2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/86589","volume":"7","author":"Drexler","year":"2001","journal-title":"Nat. Med."},{"key":"ol-46-9-2071-R3","doi-asserted-by":"publisher","first-page":"121711","DOI":"10.1117\/1.JBO.22.12.121711","volume":"22","author":"Wang","year":"2017","journal-title":"J. Biomed. Opt."},{"key":"ol-46-9-2071-R4","doi-asserted-by":"publisher","first-page":"121716","DOI":"10.1117\/1.JBO.22.12.121716","volume":"22","author":"Tsai","year":"2017","journal-title":"J. Biomed. Opt."},{"key":"ol-46-9-2071-R5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/nphys514","volume":"3","author":"Ralston","year":"2007","journal-title":"Nat. Phys."},{"key":"ol-46-9-2071-R6","doi-asserted-by":"publisher","first-page":"7175","DOI":"10.1073\/pnas.1121193109","volume":"109","author":"Adie","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ol-46-9-2071-R7","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1364\/OL.41.003324","volume":"41","author":"Paritosh","year":"2016","journal-title":"Opt. Lett."},{"key":"ol-46-9-2071-R8","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1364\/BOE.5.003417","volume":"5","author":"South","year":"2014","journal-title":"Biomed. Opt. Express"},{"key":"ol-46-9-2071-R9","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1117\/1.1644118","volume":"9","author":"Strasswimmer","year":"2004","journal-title":"J. Biomed. Opt."},{"key":"ol-46-9-2071-R10","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1364\/OE.14.001547","volume":"14","author":"Pasquesi","year":"2006","journal-title":"Opt. Express"},{"key":"ol-46-9-2071-R11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.sna.2007.04.016","volume":"142","author":"Str\u0105kowski","year":"2008","journal-title":"Sens. Actuators A, Phys."},{"key":"ol-46-9-2071-R12","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1364\/BOE.8.001838","volume":"8","author":"De Boer","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"ol-46-9-2071-R13","doi-asserted-by":"publisher","first-page":"211106","DOI":"10.1063\/1.4936236","volume":"107","author":"South","year":"2015","journal-title":"Appl. Phys. Lett."},{"key":"ol-46-9-2071-R14","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.1364\/BOE.9.006519","volume":"9","author":"Wang","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"ol-46-9-2071-R15","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1364\/OL.44.001186","volume":"44","author":"South","year":"2019","journal-title":"Opt. Lett."},{"key":"ol-46-9-2071-R16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1201\/b14898","volume-title":"Adaptive Optics for Biological Imaging","author":"Kubby","year":"2013"},{"key":"ol-46-9-2071-R17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-540-77550-8_2","volume-title":"Optical Coherence Tomography","author":"Izatt","year":"2008"},{"key":"ol-46-9-2071-R18","doi-asserted-by":"publisher","first-page":"28771","DOI":"10.1038\/srep28771","volume":"6","author":"Villiger","year":"2016","journal-title":"Sci. Rep."},{"key":"ol-46-9-2071-R19","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1364\/OL.37.001415","volume":"37","author":"Fan","year":"2012","journal-title":"Opt. Lett."},{"key":"ol-46-9-2071-R20","doi-asserted-by":"publisher","first-page":"19412","DOI":"10.1364\/OE.21.019412","volume":"21","author":"Ju","year":"2013","journal-title":"Opt. Express"},{"key":"ol-46-9-2071-R21","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1364\/OL.40.001779","volume":"40","author":"Zhi","year":"2015","journal-title":"Opt. Lett."}],"container-title":["Optics Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=ol-46-9-2071&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T19:29:37Z","timestamp":1722972577000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=ol-46-9-2071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021]]},"published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1364\/ol.418637","relation":{},"ISSN":["0146-9592","1539-4794"],"issn-type":[{"value":"0146-9592","type":"print"},{"value":"1539-4794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/OL.418637","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"letter","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"6 January 2021","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"10 March 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"21 April 2021","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2021 Optical Society of America","name":"copyright","label":"Copyright"}]}}