{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:47:39Z","timestamp":1789015659421,"version":"build-2803163510"},"reference-count":22,"publisher":"Optica Publishing Group","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR"},{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Opt. Lett."],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>Observation and characterization of any changes in anatomical structures of ocular components remain as a conventional technique for diagnosis, staging, therapeutic treatments, and post-treatment monitoring of any ophthalmic disorders. The existing technologies fail to provide imaging of all of the various components of the eye simultaneously at one scanning time, i.e., one can recover vital patho-physiological information (structure and bio-molecular content) of the different ocular tissue sections only one after another. This article addresses the longstanding technological challenge by use of an emerging imaging modality [photoacoustic imaging (PAI)] in which we integrated a synthetic aperture reconstruction technique (SAFT). Experimental results\u2014with experiments being conducted in excised tissues (goat eye)\u2014demonstrated that we can simultaneously image the entire structure of the eye (\u223c2.5 cm) depicting clearly the distinctive ocular structures (cornea, aqueous humor, iris, pupil, eye lens, vitreous humor, and retina). This study uniquely opens an avenue for promising ophthalmic (clinical) applications of high clinical impact.<\/jats:p>","DOI":"10.1364\/ol.487260","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T10:00:56Z","timestamp":1684836056000},"page":"3443","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High-resolution imaging of the whole eye with photoacoustic microscopy"],"prefix":"10.1364","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-3101","authenticated-orcid":true,"given":"Deepayan","family":"Samanta","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pe3t004","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-6087","authenticated-orcid":true,"given":"Souradip","family":"Paul","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pe3t004","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-3337","authenticated-orcid":true,"given":"Arijit","family":"Paramanick","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pe3t004","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal R","family":"Raval","sequence":"additional","affiliation":[{"name":"L V Prasad Eye Institute (LVPEI)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-0846","authenticated-orcid":true,"given":"Mayanglambam","family":"Suheshkumar Singh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pe3t004","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ol-48-13-3443-R1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pacs.2016.05.001","volume":"4","author":"Liu","year":"2016","journal-title":"Photoacoustics"},{"key":"ol-48-13-3443-R2","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1006\/exer.1998.0622","volume":"68","author":"Alroy","year":"1999","journal-title":"Exp. Eye Res."},{"key":"ol-48-13-3443-R3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3980\/j.issn.2222-3959.2015.01.32","volume":"8","author":"Abdelfattah","year":"2015","journal-title":"Int. J. Ophthalmol."},{"key":"ol-48-13-3443-R4","doi-asserted-by":"publisher","first-page":"4370","DOI":"10.1167\/iovs.07-0964","volume":"49","author":"Usui","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ol-48-13-3443-R5","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1364\/OL.35.000270","volume":"35","author":"de La Zerda","year":"2010","journal-title":"Opt. Lett."},{"key":"ol-48-13-3443-R6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1364\/OL.35.000001","volume":"35","author":"Hu","year":"2010","journal-title":"Opt. Lett."},{"key":"ol-48-13-3443-R7","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.1364\/OE.18.003967","volume":"18","author":"Jiao","year":"2010","journal-title":"Opt. Express"},{"key":"ol-48-13-3443-R8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.ultrasmedbio.2010.02.006","volume":"36","author":"Silverman","year":"2010","journal-title":"Ultrasound. Med. Biol."},{"key":"ol-48-13-3443-R9","doi-asserted-by":"publisher","first-page":"061206","DOI":"10.1117\/1.JBO.17.6.061206","volume":"17","author":"Song","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"ol-48-13-3443-R10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.exer.2015.05.022","volume":"138","author":"Hennen","year":"2015","journal-title":"Exp. Eye Res."},{"key":"ol-48-13-3443-R11","doi-asserted-by":"publisher","first-page":"6525","DOI":"10.1038\/srep06525","volume":"4","author":"Song","year":"2014","journal-title":"Sci. Rep."},{"key":"ol-48-13-3443-R12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.pacs.2014.04.003","volume":"2","author":"Liu","year":"2014","journal-title":"Photoacoustics"},{"key":"ol-48-13-3443-R13","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1364\/OL.39.002451","volume":"39","author":"Wu","year":"2014","journal-title":"Opt. Lett."},{"key":"ol-48-13-3443-R14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/jbio.201200061","volume":"6","author":"Song","year":"2013","journal-title":"J. Biophotonics"},{"key":"ol-48-13-3443-R15","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3109\/02713683.2013.815219","volume":"38","author":"Liu","year":"2013","journal-title":"Curr. Eye Res."},{"key":"ol-48-13-3443-R16","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1080\/09500340.2011.601331","volume":"58","author":"Wei","year":"2011","journal-title":"J. Mod. Opt."},{"key":"ol-48-13-3443-R17","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1364\/OL.40.001370","volume":"40","author":"Liu","year":"2015","journal-title":"Opt. Lett."},{"key":"ol-48-13-3443-R18","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1364\/BOE.3.000792","volume":"3","author":"Liu","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ol-48-13-3443-R19","doi-asserted-by":"publisher","first-page":"051704","DOI":"10.3788\/COL201412.051704","volume":"12","author":"Song","year":"2014","journal-title":"Chin. Opt. Lett."},{"key":"ol-48-13-3443-R20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/s41377-018-0093-y","volume":"7","author":"Zhang","year":"2018","journal-title":"Light: Sci. Appl."},{"key":"ol-48-13-3443-R21","doi-asserted-by":"publisher","first-page":"e202200157","DOI":"10.1002\/jbio.202200157","volume":"16","author":"Thomas","year":"2023","journal-title":"J. Biophotonics"},{"key":"ol-48-13-3443-R22","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3390\/s21041190","volume":"21","author":"Thomas","year":"2021","journal-title":"Sensors"}],"container-title":["Optics Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=ol-48-13-3443&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:34:07Z","timestamp":1722958447000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=ol-48-13-3443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":22,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1364\/ol.487260","relation":{},"ISSN":["0146-9592","1539-4794"],"issn-type":[{"value":"0146-9592","type":"print"},{"value":"1539-4794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/OL.487260","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"letter","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"8 February 2023","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"22 May 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"21 June 2023","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2023 Optica Publishing Group","name":"copyright","label":"Copyright"}]}}