{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:03:39Z","timestamp":1792249419392,"version":"4.4.0"},"reference-count":16,"publisher":"Optica Publishing Group","issue":"14","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/501100013388","name":"Office National d'\u00e9tudes et de Recherches A\u00e9rospatiales","doi-asserted-by":"publisher","award":["PRF TELEMAC"],"award-info":[{"award-number":["PRF TELEMAC"]}],"id":[{"id":"10.13039\/501100013388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-IAHU-0001"],"award-info":[{"award-number":["ANR-18-IAHU-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE19-0010-01"],"award-info":[{"award-number":["ANR-22-CE19-0010-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Opt. Lett."],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:p>We demonstrate the feasibility of a multimodal adaptive optics flood-illumination ophthalmoscope, able to provide both bright-field and dark-field images (such as phase contrast). The multimodality was made possible by integrating a digital micromirror device (DMD) at the illumination path to project a sequence of complementary high-resolution patterns into the retina. Through a versatile post-processing method that digitally selects backscattered or multiply scattered photons, we were able: (1) to achieve up to four-fold contrast increase of bright-field images when imaging the photoreceptor mosaic and nerve fibers; and (2) to visualize translucent retinal features such as capillaries, red blood cells, vessel walls, ganglion cells, and photoreceptor inner segments through phase contrast.<\/jats:p>","DOI":"10.1364\/ol.495515","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:00:07Z","timestamp":1688119207000},"page":"3785","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multimodal high-resolution retinal imaging using a camera-based DMD-integrated adaptive optics flood-illumination ophthalmoscope"],"prefix":"10.1364","volume":"48","author":[{"given":"L\u00e9a","family":"Krafft","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Saclay F-91123 Palaiseau"},{"name":"Quinze-Vingts National Ophthalmology Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sen\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay F-91123 Palaiseau"},{"name":"Quinze-Vingts National Ophthalmology Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-0373","authenticated-orcid":true,"given":"Elena","family":"Gofas","sequence":"additional","affiliation":[{"name":"Quinze-Vingts National Ophthalmology Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Thouvenin","sequence":"additional","affiliation":[{"name":"PSL University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-6419","authenticated-orcid":true,"given":"Michael","family":"Atlan","sequence":"additional","affiliation":[{"name":"Quinze-Vingts National Ophthalmology Hospital"},{"name":"PSL University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Paques","sequence":"additional","affiliation":[{"name":"Quinze-Vingts National Ophthalmology Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-9443","authenticated-orcid":true,"given":"Serge","family":"Meimon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay F-91123 Palaiseau"},{"name":"Quinze-Vingts National Ophthalmology Hospital"},{"name":"PSL University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-3999","authenticated-orcid":true,"given":"Pedro","family":"Mec\u00ea","sequence":"additional","affiliation":[{"name":"Quinze-Vingts National Ophthalmology Hospital"},{"name":"PSL University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"ol-48-14-3785-R1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1364\/OE.10.000405","volume":"10","author":"Roorda","year":"2002","journal-title":"Opt. Express"},{"key":"ol-48-14-3785-R2","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1364\/BOE.3.002537","volume":"3","author":"Chui","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ol-48-14-3785-R3","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1364\/BOE.396937","volume":"11","author":"Mec\u00ea","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"ol-48-14-3785-R4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1364\/BOE.441808","volume":"13","author":"Gofas-Salas","year":"2022","journal-title":"Biomed. Opt. Express"},{"key":"ol-48-14-3785-R5","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1364\/OL.417903","volume":"46","author":"Mec\u00ea","year":"2021","journal-title":"Opt. Lett."},{"key":"ol-48-14-3785-R6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.6.2.9","volume":"6","author":"Salmon","year":"2017","journal-title":"Trans. Vis. Sci. Tech."},{"key":"ol-48-14-3785-R7","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1364\/AO.57.005635","volume":"57","author":"Gofas-Salas","year":"2018","journal-title":"Appl. Opt."},{"key":"ol-48-14-3785-R8","first-page":"4641","volume":"59","author":"Meimon","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ol-48-14-3785-R9","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1364\/BOE.10.002730","volume":"10","author":"Gofas-Salas","year":"2019","journal-title":"Biomed. Opt. Express"},{"key":"ol-48-14-3785-R10","doi-asserted-by":"publisher","first-page":"9951","DOI":"10.1364\/AO.428048","volume":"60","author":"Krafft","year":"2021","journal-title":"Appl. Opt."},{"key":"ol-48-14-3785-R11","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1364\/OL.480688","volume":"48","author":"Lee","year":"2023","journal-title":"Opt. Lett."},{"key":"ol-48-14-3785-R12","doi-asserted-by":"publisher","first-page":"e0169358","DOI":"10.1371\/journal.pone.0169358","volume":"12","author":"Lu","year":"2017","journal-title":"PLoS One"},{"key":"ol-48-14-3785-R14","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/nmeth.2219","volume":"9","author":"Ford","year":"2012","journal-title":"Nat. Methods"},{"key":"ol-48-14-3785-R15","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1364\/OL.382589","volume":"45","author":"Guevara-Torres","year":"2020","journal-title":"Opt. Lett."},{"key":"ol-48-14-3785-R16","doi-asserted-by":"publisher","first-page":"5901","DOI":"10.1364\/OL.403135","volume":"45","author":"Scholler","year":"2020","journal-title":"Opt. Lett."},{"key":"ol-48-14-3785-R17","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1364\/BOE.4.001710","volume":"4","author":"Scoles","year":"2013","journal-title":"Biomed. Opt. Express"}],"container-title":["Optics Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=ol-48-14-3785&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:32:55Z","timestamp":1722958375000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=ol-48-14-3785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":16,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1364\/ol.495515","relation":{"has-preprint":[{"id-type":"doi","id":"10.1364\/opticaopen.22769519","asserted-by":"subject"},{"id-type":"doi","id":"10.1364\/opticaopen.22769519.v1","asserted-by":"object"},{"id-type":"doi","id":"10.1364\/opticaopen.22769519","asserted-by":"object"}],"is-supplemented-by":[{"id-type":"doi","id":"10.1364\/opticaopen.22769519","asserted-by":"object"},{"id-type":"doi","id":"10.1364\/opticaopen.22769519.v1","asserted-by":"object"}]},"ISSN":["0146-9592","1539-4794"],"issn-type":[{"value":"0146-9592","type":"print"},{"value":"1539-4794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/OL.495515","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"letter","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"15 May 2023","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"28 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"11 July 2023","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2023 Optica Publishing Group","name":"copyright","label":"Copyright"}]}}