{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:03:22Z","timestamp":1785409402304,"version":"3.56.0"},"reference-count":33,"publisher":"Optica Publishing Group","issue":"2","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v2#VOR"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["Pathfinder Open Project 101130161 - Move2Treat"],"award-info":[{"award-number":["Pathfinder Open Project 101130161 - Move2Treat"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R380-2021-1171"],"award-info":[{"award-number":["R380-2021-1171"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R276-2018-869 - Multi-BRAIN"],"award-info":[{"award-number":["R276-2018-869 - Multi-BRAIN"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Opt. Lett."],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:p>\n                    Optical fibers are between the most common implantable devices for delivering light in the nervous system for optogenetics and infrared neural stimulation applications. Tapered optical fibers, in particular, can offer homogeneous light delivery to a large volume and spatially resolved illumination compared to standard flat-cleaved fibers while being minimally invasive. However, the use of tapers for neural applications has up to now been limited to silica optical fibers, whose large Young\u2019s modulus can cause detrimental foreign body response in chronic settings. Here, we present the fabrication and optimization of tapered fiber implants based on polymer optical fibers (POFs). After numerically determining the optimal materials and taper geometry, we fabricated two types of POFs by thermal fiber drawing. The fabrication of the taper was achieved by chemical etching of the fibers, for which several solvents previously reported in literature have been tested. The influence of different parameters on the etching process and on the quality of the obtained tapers was also investigated. The large illumination volume of the produced high-quality taper-based implants was finally tested\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    in a brain phantom.\n                  <\/jats:p>","DOI":"10.1364\/ol.546470","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:00:10Z","timestamp":1732273210000},"page":"670","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Soft biocompatible polymer optical fiber tapers for implantable neural devices"],"prefix":"10.1364","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-442X","authenticated-orcid":true,"given":"Marcello","family":"Meneghetti","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qtj9h94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qtj9h94","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyang","family":"Sui","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qtj9h94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune W.","family":"Berg","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-5275","authenticated-orcid":true,"given":"Christos","family":"Markos","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qtj9h94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NORBLIS ApS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ol-50-2-670-R1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0896-6273(01)00574-8","volume":"33","author":"Zemelman","year":"2002","journal-title":"Neuron"},{"key":"ol-50-2-670-R2","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/nn1525","volume":"8","author":"Boyden","year":"2005","journal-title":"Nat. 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Phys."}],"container-title":["Optics Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/opg.optica.org\/viewmedia.cfm?URI=ol-50-2-670&seq=0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T10:06:03Z","timestamp":1736935563000},"score":1,"resource":{"primary":{"URL":"https:\/\/opg.optica.org\/abstract.cfm?URI=ol-50-2-670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025]]},"published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1364\/ol.546470","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.29.620629","asserted-by":"object"}]},"ISSN":["0146-9592","1539-4794"],"issn-type":[{"value":"0146-9592","type":"print"},{"value":"1539-4794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"Optica Publishing Group","name":"publisher","label":"This article is maintained by"},{"value":"https:\/\/doi.org\/10.1364\/OL.546470","name":"articlelink","label":"Crossref DOI link to publisher maintained version"},{"value":"letter","name":"content_type","label":"Article type"},{"value":"Screened by Similarity Check","name":"cross_check","label":"Similarity check"},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"29 October 2024","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"21 November 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"15 January 2025","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2025 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.","name":"copyright","label":"Copyright"}]}}