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Lett."],"published-print":{"date-parts":[[2026,2,15]]},"abstract":"<jats:p>The elasticity of luminal tissues is closely associated with disease progression and functional status. Endoscopic optical coherence elastography (OCE) has emerged as a promising technique for assessing the mechanical properties of luminal tissues. However, previous endoscopic OCE approaches typically measure elasticity along only a single direction\u2014either laterally or in depth\u2014thereby potentially leading to an inaccurate estimation of anisotropic tissue mechanics. In this study, we propose a forward-scanning endoscopic OCE method that enables quantitative measurement of tissue elasticity in both the lateral and depth directions, allowing direct characterization of anisotropic mechanical properties in luminal tissues. An air-pulse excitation was applied to generate Rayleigh waves and longitudinal shear waves in agar phantoms and ex vivo gastric tissues. Elastic wave propagation was detected using phase-resolved Doppler optical coherence tomography. Experimental results demonstrate that the proposed method can quantitatively assess anisotropic elasticity with a forward-viewing configuration, highlighting its potential for clinical diagnosis and biomechanical characterization of luminal tissues.<\/jats:p>","DOI":"10.1364\/ol.585539","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T17:00:10Z","timestamp":1769446810000},"page":"1001","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Forward-scanning endoscopic optical coherence elastography for elasticity measurements of anisotropic tissues"],"prefix":"10.1364","volume":"51","author":[{"given":"Chongyang","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-8358","authenticated-orcid":true,"given":"Xiaochen","family":"Meng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5225-8668","authenticated-orcid":true,"given":"Jiawei","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqing","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-2761","authenticated-orcid":true,"given":"Fan","family":"Fan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2601-4967","authenticated-orcid":true,"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xnqep60","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Beijing Information Science and Technology University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ol-51-4-1001-R1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1309\/LBGTCG1QCD96M3NF","type":"journal-article","volume":"122","author":"Hobbs","year":"2004","journal-title":"Am. 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All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.","name":"copyright","label":"Copyright"}]}}