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Lett."],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>Single-shot quantitative phase imaging (QPI) promises high-speed, label-free observation of dynamic biological processes, but remains challenged by limited reconstruction fidelity, weak-object assumptions, and the inability to recover both amplitude and large phase delays. In this Letter, we introduce CMKK-QPI, a single-shot QPI framework that synergizes color-multiplexed oblique illumination with iterative processing based on the Kramers\u2013Kronig (KK) relations. By spectrally encoding angular diversity into a single color exposure, CMKK-QPI enables simultaneous acquisition of multiple intensity measurements without sacrificing temporal resolution. An initial complex-field estimate is retrieved via the KK relations and iteratively refined to jointly reconstruct amplitude and phase. Experiments on resolution targets, biological tissues, and live cells demonstrate that CMKK-QPI achieves a resolution corresponding to twice the coherent diffraction limit and phase accuracy comparable to multi-frame Fourier ptychographic microscopy, with only a single exposure and convergence within 5 iterations. Importantly, CMKK-QPI robustly handles large phase variations and enables long-term, high-speed imaging of dynamic cellular morphology at 30\u2009Hz. With minimal data redundancy and high computational efficiency, CMKK-QPI provides a practical solution for high-speed, label-free imaging of dynamic biological samples.<\/jats:p>","DOI":"10.1364\/ol.596621","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:00:09Z","timestamp":1779897609000},"page":"3685","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-shot color-multiplexed quantitative phase imaging with Kramers\u2013Kronig relations"],"prefix":"10.1364","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6826-805X","authenticated-orcid":true,"given":"Qian","family":"Shen","sequence":"first","affiliation":[{"name":"Nanjing University of Science and Technology"},{"name":"Smart Computational Imaging Research Institute of Nanjing University of Science and Technology"},{"name":"Jiangsu Key Laboratory of Visual Sensing & Intelligent Perception, Nanjing, 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