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Lett."],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:p>Optoretinography (ORG) typically measures rapid photoreceptor responses, limiting investigation of slower retinal recovery processes. Here, we demonstrate long-duration volumetric ORG using customized high-resolution spectral-domain optical coherence tomography with repeated volumetric acquisition. Spatial averaging across the retinal volume improves sensitivity to both light-evoked scattering and outer segment (OS) optical path length (OPL) changes, while automated deep learning-based segmentation enables efficient analysis of large four-dimensional (4D) datasets. In vivo experiments in mice reveal distinct phases of retinal recovery dynamics extending over 30\u2009min after photostimulation. Preliminary comparative measurements further reveal altered recovery behavior and an attenuated early OS OPL response in aged mice. 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All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.","name":"copyright","label":"Copyright"}]}}