{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:01:15Z","timestamp":1760853675691,"version":"3.38.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Appl Spectrosc"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p> Laser-induced fluorescence (LIF) and intrinsic fluorescence spectroscopy (IFS) have been used experimentally for diagnosing coronary atherosclerosis. In this study, we demonstrated the diagnostic superiority of IFS at 342-nm excitation (IFS<jats:sub>342<\/jats:sub>) versus LIF (LIF<jats:sub>342<\/jats:sub>) and described a protocol for head-to-head comparison of old (LIF) versus new (IFS) generations of similar diagnostic methods, labeled as \u201cgenerational comparison model\u201c. IFS<jats:sub>342<\/jats:sub> and LIF<jats:sub>342<\/jats:sub> were modeled with basis spectra of media, fibrous caps, and superficial foam cells and of their correspondent chemicals (elastin, collagen, and lipoproteins). The average accuracy and receiver operating characteristic area under the curve of IFS<jats:sub>342<\/jats:sub> in single-, double-, and triple-parameter diagnostic algorithm iterations, geared toward identifying 84 atherosclerotic specimens from a group of 117 coronary segments, was 90% \u00b1 1% and 0.87 \u00b1 0.025, superior to LIF<jats:sub>342<\/jats:sub> (84% \u00b1 3% and 0.84 \u00b1 0.016; P = 0.0002 and 0.02, respectively) in a generational comparison model. <\/jats:p>","DOI":"10.1366\/11-06566","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T04:38:24Z","timestamp":1355200704000},"page":"1403-1410","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Intrinsic versus Laser-Induced Fluorescence Spectroscopy for Coronary Atherosclerosis: A Generational Comparison Model for Testing Diagnostic Accuracy"],"prefix":"10.1177","volume":"66","author":[{"given":"George O.","family":"Angheloiu","sequence":"first","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Department of Cardiology, Dubois Regional Medical Center, Dubois, PA 15801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweder W.E.","family":"van de Poll","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Department of Cardiology, St. Franciscus Gasthuis, Kleiweg 500, 3045 PM, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Georgakoudi","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Department of Biomedical Engineering, Tufts University, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason T.","family":"Motz","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail S.","family":"Haka","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Podrez","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryann","family":"Fitzmaurice","sequence":"additional","affiliation":[{"name":"University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandra R.","family":"Dasari","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Feld","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"bibr1-11-06566","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.36"},{"key":"bibr2-11-06566","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.007"},{"key":"bibr3-11-06566","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.018"},{"key":"bibr4-11-06566","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.6.1893"},{"key":"bibr5-11-06566","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000225699.36212.23"},{"key":"bibr6-11-06566","doi-asserted-by":"publisher","DOI":"10.1161\/hq0701.092091"},{"key":"bibr7-11-06566","first-page":"011009\/1\u201310","volume":"16","author":"Scepanovic O.R.","year":"2011","journal-title":"J. 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