{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:56:07Z","timestamp":1782885367566,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Appl Spectrosc"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p> The photoionization properties of the pharmaceutically relevant substances amantadine, diazepam, dimethyltryptamine, etomidate, ketamine, mescaline, methadone, and propofol were determined. At beamline U125\/2-10m-NIM of the BESSY II synchrotron facility (Berlin, Germany) vacuum ultraviolet (VUV) photoionization spectra were recorded in the energy range 7.1 to 11.9 eV (174.6 to 104.2 nm), showing the hitherto unknown ionization energies and fragmentation appearance energies of the compounds under investigation. Furthermore, (1+1)-resonance-enhanced multiphoton ionization (REMPI) spectra of selected compounds (amantadine, diazepam, etomidate, ketamine, and propofol) were recorded by a continuous scan in the energy range between 3.6 and 5.7 eV (345 to 218 nm) using a tunable optical parametric oscillator (spectral resolution: 0.1 nm) laser system. The resulting REMPI wavelength spectra of these compounds are discussed and put into context with already known UVabsorption data. Time-of-flight mass spectrometry was used for ion detection in both experiments. Finally, the implications of the obtained physical-chemical results for potential analytical applications are discussed. In this context, fast detection approaches for the considered compounds from breath gas using photoionization mass spectrometry and a rapid pre-concentration step (e.g., needle trap device) are of interest. <\/jats:p>","DOI":"10.1366\/13-06988","type":"journal-article","created":{"date-parts":[[2013,7,21]],"date-time":"2013-07-21T04:35:40Z","timestamp":1374381340000},"page":"860-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of the Photoionization Properties of Pharmaceutically Relevant Substances by Resonance-Enhanced Multiphoton Ionization Spectroscopy and Single-Photon Ionization Spectroscopy Using Synchrotron Radiation"],"prefix":"10.1177","volume":"67","author":[{"given":"Juliane","family":"Kleeblatt","sequence":"first","affiliation":[{"name":"Joint Mass Spectrometry Center, Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, 18059 Rostock, Germany and Comprehensive Molecular Analytics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Ehlert","sequence":"additional","affiliation":[{"name":"Joint Mass Spectrometry Center, Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, 18059 Rostock, Germany and Comprehensive Molecular Analytics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"H\u00f6lzer","sequence":"additional","affiliation":[{"name":"Joint Mass Spectrometry Center, Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, 18059 Rostock, Germany and Comprehensive Molecular Analytics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sklorz","sequence":"additional","affiliation":[{"name":"Joint Mass Spectrometry Center, Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, 18059 Rostock, Germany and Comprehensive Molecular Analytics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rittgen","sequence":"additional","affiliation":[{"name":"Joint Mass Spectrometry Center, Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, 18059 Rostock, Germany and Comprehensive Molecular Analytics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"},{"name":"BKA Bundeskriminalamt, 65173 Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Baumg\u00e4rtel","sequence":"additional","affiliation":[{"name":"Helmholtz-Zentrum Berlin, BESSY II, Institute of Nanometre Optics and Technology, 12489 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen K.","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, University of Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Joint Mass Spectrometry Center, Chair of Analytical Chemistry, Institute of Chemistry, University of Rostock, 18059 Rostock, Germany and Comprehensive Molecular Analytics, Helmholtz Zentrum M\u00fcnchen, 85764 Neuherberg, Germany"},{"name":"Bifa Umweltinstitut GmbH, 86167 Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,8,1]]},"reference":[{"key":"bibr1-13-06988","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.10.2374"},{"key":"bibr2-13-06988","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-005-1158-z"},{"key":"bibr3-13-06988","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2011.09.013"},{"key":"bibr4-13-06988","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07552-7"},{"key":"bibr5-13-06988","doi-asserted-by":"publisher","DOI":"10.1021\/ac960749l"},{"key":"bibr6-13-06988","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.02.090"},{"key":"bibr7-13-06988","doi-asserted-by":"publisher","DOI":"10.1039\/a827347z"},{"key":"bibr8-13-06988","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-5099-8"},{"key":"bibr9-13-06988","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20033"},{"key":"bibr10-13-06988","doi-asserted-by":"publisher","DOI":"10.1021\/ac8013675"},{"key":"bibr11-13-06988","doi-asserted-by":"publisher","DOI":"10.1002\/9780470027318.a0714"},{"issue":"22","key":"bibr12-13-06988","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1021\/ac049535r","volume":"76","author":"M\u00fchlberger F.","year":"2004","journal-title":"Anal. 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