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However, in comparison with the hard palate, there is still a lack of information about the mechanisms of soft palate development. In this study, the authors investigated the contribution of cranial neural crest (CNC) cells to development of both hard and soft palates. They also demonstrated a unique pattern of periostin expression during soft palate development, which was closely related to that of collagen type I (Col I) in palatine aponeurosis. Furthermore, organ culture analysis showed that exogenous transforming growth factor\u2013\u03b2 (TGF-\u03b2) induced the expression of both periostin and Col I. These novel patterns of expression in the extracellular matrix (ECM) induced by CNC cells suggest that these cells may help to determine the character of both the hard and soft palates through ECM induction. TGF-\u03b2 signaling appears to be one of the mediators of Col I and periostin expression in the formation of functional structures during soft palate development.<\/jats:p>","DOI":"10.1369\/0022155411427059","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T19:29:32Z","timestamp":1325100572000},"page":"57-68","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Roles of Collagen and Periostin Expression by Cranial Neural Crest Cells during Soft Palate Development"],"prefix":"10.1177","volume":"60","author":[{"given":"Kyoko","family":"Oka","sequence":"first","affiliation":[{"name":"Section of Functional Structure, Division of Biomedical Sciences, Department of Morphological Biology, Fukuoka Dental College, Fukuoka, Japan (KO,ET,YH,YS)"},{"name":"Department of Anatomy (MJH,KI)"},{"name":"Dental Research Center (MJH,KI)"},{"name":"Nihon University School of Dentistry, 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