{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:43:46Z","timestamp":1777851826216,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>The human cervical cancer oncogene 1 (HCCR-1), a novel human oncoprotein, has been shown to be upregulated in various human tumors and plays a critical role in tumorigenesis and tumor progression. Here, the authors investigated HCCR-1 level in esophageal squamous cell carcinoma (ESCC) tissues and assessed the correlation between HCCR-1 level and prognosis of the patients with ESCC. HCCR-1 levels were investigated by immunohistochemistry, in situ hybridization, real-time quantitative RT-PCR and Western blotting methods; Kaplan-Meier curve was used to evaluate the prognostic value of HCCR-1 level in patients with ESCC using log-rank test. HCCR-1 displayed high levels in ESCC tissues compared to squamous dysplasia tissues and normal esophageal epithelial tissues. No significant correlation was observed between the levels of HCCR-1 mRNA and protein and gender and age (all p&gt;0.05) but obviously related to histological grade, clinical stage, and lymph node metastasis (all p&lt;0.001). Moreover, the survival rate of the patients with low HCCR-1 levels was higher than that of the patients with high HCCR-1 levels (both p&lt;0.05). These data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with ESCC.<\/jats:p>","DOI":"10.1369\/0022155412444437","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T08:49:29Z","timestamp":1334825369000},"page":"512-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Implication of Elevated Human Cervical Cancer Oncogene-1 Expression in Esophageal Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"60","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oncology (YL, QF), First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China"},{"name":"Department of Pathology (SL, HZ), First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China"},{"name":"Department of Oncology, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, PR China (YL, 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