{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:44:00Z","timestamp":1777851840771,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Islet-associated protein\u20132 (IA-2) and IA-2\u03b2 (also known as phogrin) are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs). The IA-2 family of PTPs was originally identified from insulinoma cells and discovered to be major autoantigens in type 1 diabetes. Despite its expression in the neural and canonical endocrine tissues, data on expression of the IA-2 family of PTPs in gastrointestinal endocrine cells (GECs) are limited. Therefore, we immunohistochemically investigated the expression of the IA-2 family of PTPs in the rat gastrointestinal tract. In the stomach, IA-2 and IA-2\u03b2 were expressed in GECs that secrete serotonin, somatostatin, and cholecystokinin\/gastrin-1. In addition to these hormones, secretin, gastric inhibitory polypeptide (also known as the glucose-dependent insulinotropic peptide), glucagon-like peptide-1, and glucagon, but not ghrelin were coexpressed with IA-2 or IA-2\u03b2 in duodenal GECs. Pancreatic islet cells that secrete gut hormones expressed the IA-2 family of PTPs. The expression patterns of IA-2 and IA-2\u03b2 were comparable. These results reveal that the IA-2 family of PTPs is expressed in a cell type\u2013specific manner in rat GECs. The extensive expression of the IA-2 family of PTPs in pancreo-gastrointestinal endocrine cells and in the enteric plexus suggests their systemic contribution to nutritional control through a neuroendocrine signaling network.<\/jats:p>","DOI":"10.1369\/0022155412466872","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T15:46:39Z","timestamp":1351784799000},"page":"156-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Immunohistochemical Analysis of IA-2 Family of Protein Tyrosine Phosphatases in Rat Gastrointestinal Endocrine Cells"],"prefix":"10.1177","volume":"61","author":[{"given":"Hiroshi","family":"Gomi","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, Kanagawa, Japan (HG, TY, AT)"},{"name":"Laboratory of Secretion Biology, Institute for Molecular and Cellular Regulation, Gunma 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