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In the study presented here, we evaluated the bilateral distribution of the CB2R protein and messenger RNA (mRNA) in rat dorsal root ganglia (DRG) after unilateral peripheral nerve injury using immunohistochemistry, western blot, and in situ hybridization analysis. Unilateral chronic constriction injury (CCI) of the sciatic nerve induced neuropathic pain behavior and bilateral elevation of both CB2R protein and mRNA in lumbar L4\u2013L5 as well as cervical C7\u2013C8 DRG when compared with naive animals. CB2R protein and mRNA were increased not only in DRG neurons but also in satellite glial cells. The fact that changes appear bilaterally and (albeit at a lower level) even in the remote cervical DRG can be related to propagation of neuroinflammation alongside the neuraxis and to the neuroprotective effects of CB2R.<\/jats:p>","DOI":"10.1369\/0022155413491269","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:15:05Z","timestamp":1368058505000},"page":"529-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model"],"prefix":"10.1369","volume":"61","author":[{"given":"Ivana Hradilov\u00e1","family":"Sv\u00ed\u017eensk\u00e1","sequence":"first","affiliation":[{"name":"Central European Institute of Technology (CEITEC) (IHS,VB,IK,PD)"},{"name":"Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine Masaryk University, Brno, Czech Republic (IHS,IK,PD)"},{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Brno, Czech Republic (VB)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clav","family":"Br\u00e1zda","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology (CEITEC) (IHS,VB,IK,PD)"},{"name":"Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine Masaryk University, Brno, Czech Republic (IHS,IK,PD)"},{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Brno, Czech Republic (VB)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Klus\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology (CEITEC) (IHS,VB,IK,PD)"},{"name":"Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine Masaryk University, Brno, Czech Republic (IHS,IK,PD)"},{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Brno, Czech Republic (VB)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Dubov\u00fd","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology (CEITEC) (IHS,VB,IK,PD)"},{"name":"Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine Masaryk University, Brno, Czech Republic (IHS,IK,PD)"},{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Brno, Czech Republic (VB)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"bibr1-0022155413491269","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.06.007"},{"key":"bibr2-0022155413491269","doi-asserted-by":"crossref","unstructured":"Atwood BK, Mackie K. 2010. 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