{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:44:19Z","timestamp":1777851859888,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Tumor hypoxia is associated with more aggressive behavior and resistance to chemotherapy and radiotherapy. Carbonic anhydrase IX (CA9) level increases under hypoxia and is related to poor prognostic factors. The aim of this study was to evaluate the expression of CA9 and to identify its prognostic significance in small intestinal carcinomas (SICs). CA9 expression was observed in 36% (63\/175) of SICs. CA9 expression showed significant correlation with well- and moderately differentiated tumors compared with poorly differentiated tumors ( p=0.039), tumors with no lymph node metastasis ( p=0.005), and lower stage carcinomas ( p=0.009). CA9 expression showed an inverse correlation with perineural invasion ( p=0.021) and lymphatic invasion ( p=0.022). No significant correlation was observed between CA9 expression and gross type, histological type, pathological tumor (pT) classification, vascular invasion, pancreas invasion, and retroperitoneal seeding. SICs with CA9 overexpression showed better overall survival compared with those with no or weak CA9 expression ( p=0.048). In the multivariate analysis, poorly differentiated SICs ( p&lt;0.001) and SICs with lymph node metastasis ( p=0.002) were independent poor prognostic factors. CA9 expression in SICs is more frequently associated with good prognostic markers and better overall survival; however, it is not an independent prognostic factor.<\/jats:p>","DOI":"10.1369\/0022155413512657","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T22:43:53Z","timestamp":1384209833000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Carbonic Anhydrase IX Expression is Associated with Favorable Prognostic Factors in Small Intestinal Carcinoma"],"prefix":"10.1369","volume":"62","author":[{"given":"Mi Jin","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea (MJG)"},{"name":"Bundang Jesaeng General Hospital, Seongnam, Republic of Korea (KWK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Won","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea (MJG)"},{"name":"Bundang Jesaeng General Hospital, Seongnam, Republic of Korea (KWK)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"bibr1-0022155413512657","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2019"},{"key":"bibr2-0022155413512657","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2540"},{"key":"bibr3-0022155413512657","first-page":"941","volume":"56","author":"Brizel DM","year":"1996","journal-title":"Cancer Res"},{"key":"bibr4-0022155413512657","doi-asserted-by":"crossref","unstructured":"Chang HK, Yu E, Kim J, Bae YK, Jang KT, Jung ES, Yoon GS, Kim JM, Oh YH, Bae HI, Kim GI, Jung SJ, Gu MJ, Kim JY, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong S, Lee JS, Park JY, Hong SM; Korean Small Intestinal Cancer Study Group (2010). 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