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This study aims to evaluate the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, against renal interstitial fibrosis in mice. EGCG was administrated intraperitoneally for 14 days in a mouse model of unilateral ureteral obstruction (UUO). The results of our histological examination showed that EGCG alleviated glomerular and tubular injury and attenuated renal interstitial fibrosis in UUO mice. Furthermore, the inflammatory responses induced by UUO were inhibited, as represented by decreased macrophage infiltration and inflammatory cytokine production. Additionally, the expression of type I and III collagen in the kidney were reduced by EGCG, which indicated an inhibition of extracellular matrix accumulation. EGCG also caused an up-regulation in \u03b1-smooth muscle actin expression and a down-regulation in E-cadherin expression, indicating the inhibition of epithelial-to-mesenchymal transition. These changes were found to be in parallel with the decreased level of TGF-\u03b21 and phosphorylated Smad. In conclusion, the present study demonstrates that EGCG could attenuate renal interstitial fibrosis in UUO mice, and this renoprotective effect might be associated with its effects of inflammatory responses alleviation and TGF-\u03b2\/Smad signaling pathway inhibition.<\/jats:p>","DOI":"10.1369\/0022155414568019","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T23:15:11Z","timestamp":1419981311000},"page":"270-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Epigallocatechin-3-Gallate Attenuates Unilateral Ureteral Obstruction-Induced Renal Interstitial Fibrosis in Mice"],"prefix":"10.1369","volume":"63","author":[{"given":"Yanqiu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology (YW, FD, XS, GS, GZ, XB), Shengjing Hospital of China Medical University, People\u2019s Republic of China"},{"name":"Department of Laboratory 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