{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:29:39Z","timestamp":1789874979356,"version":"4.0.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>MGd1, a monoclonal antibody raised against gastric cancer cells, possesses a high degree of specificity for gastric cancer (GC). Here we identified that the antigen of MGd1 is CEACAM5, and used MGd1 to investigate the expression of CEACAM5 in non-GC and GC tissues (N=643), as a biomarker for prewarning and prognosis. The expression of CEACAM5 was detected by immunohistochemistry in numerous tissues; its clinicopathological correlation was statistically analyzed. CEACAM5 expression was increased progressively from normal gastric mucosa to chronic atrophic gastritis, intestinal metaplasia, dysplasia and finally to GC ( p&lt;0.05). In gastric precancerous lesions (intestinal metaplasia and dysplasia), CEACAM5-positive patients had a higher risk of developing GC as compared with CEACAM5-negative patients (OR = 12.68, p&lt;0.001). Besides, CEACAM5 was found positively correlated with invasion depth of gastric adenocarcinoma ( p&lt;0.001). In survival analysis, CEACAM5 was demonstrated to be an independent prognostic predictor for patients with GC of clinical stage IIIA\/IV ( p=0.033). Our results demonstrate that CEACAM5 is a promising biomarker for GC prewarning and prognostic evaluation.<\/jats:p>","DOI":"10.1369\/0022155415609098","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T22:10:26Z","timestamp":1442355026000},"page":"922-930","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Identification of CEACAM5 as a Biomarker for Prewarning and Prognosis in Gastric Cancer"],"prefix":"10.1369","volume":"63","author":[{"given":"Jinfeng","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi\u2019an, China (JZ, NC, FZ, JD, YN, DF)"},{"name":"Institute of Plastic Surgery of the Chinese PLA, Fourth Military Medical University, Xi\u2019an, China 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