{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:43:07Z","timestamp":1793054587379,"version":"4.5.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    In this study, we aimed to evaluate the influence of diet-induced obesity on IL-6 deficiency-induced bone remodeling abnormality. Seven-week-old IL-6\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice and their wild type (WT) littermates were fed a standard diet (SD) or high-fat diet (HFD) for 25 weeks. Lipid formation and bone metabolism in mice tibiae were investigated by histochemical analysis. Both IL-6\n                    <jats:sup>-\/-<\/jats:sup>\n                    and WT mice fed the HFD showed notable body weight gain, thickened cortical bones, and adipose accumulation in the bone marrow. Notably, the HFD normalized the bone phenotype of IL-6\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice to that of their WT counterpart, as characterized by a decrease in bone mass and the presence of an obliquely arranged, plate-like morphology in the trabecular bone. Alkaline phosphatase and osteocalcin expressions were attenuated in both genotypes after HFD feeding, especially for the IL-6\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice. Meanwhile, tartrate-resistant acid phosphatase staining was inhibited, osteoclast apoptosis rate down-regulated (revealed by TUNEL assay), and the proportion of cathepsin K (CK)-positive osteoclasts significantly increased in IL-6\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice on a HFD as compared with IL-6\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice on standard chow. Our results demonstrate that HFD-induced obesity reverses IL-6 deficiency-associated bone metabolic disorders by suppressing osteoblast activity, upregulating osteoclastic activity, and inhibiting osteoclast apoptosis.\n                  <\/jats:p>","DOI":"10.1369\/0022155415611931","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T23:09:24Z","timestamp":1443481764000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Long-Term Administration of High-Fat Diet Corrects Abnormal Bone Remodeling in the Tibiae of Interleukin-6-Deficient Mice"],"prefix":"10.1369","volume":"64","author":[{"given":"Wei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine(TH, NA) and Department of Advanced Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan (Y)"},{"name":"Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (KO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine(TH, NA) and Department of Advanced Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan (Y)"},{"name":"Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (KO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine(TH, NA) and Department of Advanced Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan (Y)"},{"name":"Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (KO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine(TH, NA) and Department of Advanced Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan (Y)"},{"name":"Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (KO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine(TH, NA) and Department of Advanced Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan (Y)"},{"name":"Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (KO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuchun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine(TH, NA) and Department of Advanced Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan (Y)"},{"name":"Division of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (KO)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Bone Metabolism, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China (WF, BL, DL, WW, XH, JC, ML)"},{"name":"Department of 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