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Recent experiments discovered that neurons within the auditory nerve exhibit basal levels of EGFR+XPA co-expression. This finding implied that auditory neurons in particular or neurons in general have the capacity to mobilize an EGFR+XPA defense. Therefore, the current study tested the hypothesis that noise stress would alter the expression pattern of EGFR\/XPA within the auditory nerve. Design-based stereology was used to quantify the proportion of neurons that expressed EGFR, XPA, and EGFR+XPA with and without noise stress. The results revealed an intricate neuronal response that is suggestive of alterations to both co-expression and individual expression of EGFR and XPA. In both the apical and middle cochlear coils, the noise stress depleted EGFR+XPA expression. Furthermore, there was a reduction in the proportion of neurons that expressed XPA-alone in the middle coils. However, the noise stress caused a significant increase in the proportion of neurons that expressed EGFR-alone in the middle coils. The basal cochlear coils failed to mobilize a significant response to the noise stress. These results suggest that EGFR and XPA might be part of the molecular defense repertoire of the auditory nerve.<\/jats:p>","DOI":"10.1369\/0022155416683661","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T09:49:10Z","timestamp":1483782550000},"page":"173-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Noise Stress Induces an Epidermal Growth Factor Receptor\/Xeroderma Pigmentosum\u2013A Response in the Auditory Nerve"],"prefix":"10.1369","volume":"65","author":[{"given":"O\u2019neil W.","family":"Guthrie","sequence":"first","affiliation":[{"name":"Cell & Molecular Pathology Laboratory, Department of Communication Sciences and Disorders, Northern Arizona University, Flagstaff, Arizona (OWG)"},{"name":"Research Service-151, Loma Linda Veterans Affairs Medical Center, Loma Linda, California (OWG)"},{"name":"Department of Otolaryngology and Head & Neck Surgery, School of Medicine, Loma Linda University Medical Center, Loma Linda, California (OWG)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"bibr1-0022155416683661","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-2-221"},{"key":"bibr2-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.59"},{"key":"bibr3-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.4.1984"},{"key":"bibr4-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.3.1335"},{"key":"bibr5-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.083022"},{"key":"bibr6-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2011.03.001"},{"key":"bibr7-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-4"},{"key":"bibr8-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31829795e9"},{"key":"bibr9-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws317"},{"key":"bibr10-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00046-9"},{"key":"bibr11-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.01.004"},{"key":"bibr12-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09619.2001"},{"key":"bibr13-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03430.x"},{"key":"bibr14-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00578-08"},{"key":"bibr15-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2015.10.001"},{"key":"bibr16-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.05.015"},{"key":"bibr17-0022155416683661","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.721828"},{"key":"bibr18-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.09.001"},{"key":"bibr19-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403046200"},{"key":"bibr20-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.10.025"},{"key":"bibr21-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.01.013"},{"key":"bibr22-0022155416683661","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.15047"},{"key":"bibr23-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00203-8"},{"key":"bibr24-0022155416683661","doi-asserted-by":"publisher","DOI":"10.7874\/jao.2015.19.3.111"},{"key":"bibr25-0022155416683661","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2130-4"},{"key":"bibr26-0022155416683661","author":"Guthrie OW","journal-title":"Assoc. 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