{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:36:39Z","timestamp":1783474599217,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Here, we report the first molecular cytogenetic characterization of the BALB\/cAnN mouse derived B-cell non-Hodgkin lymphoma (B-cell NHL) cell lines A-20. Even though previously used as a model for testing of, for example, dexametason, up to present, no data in the genetic properties of A-20 were available. The present study closed this gap and provides evidence that A-20 is a model for B-cell NHL subgroup sporadic Burkitt\u2019s lymphoma. C-myc oncogene is involved in a translocation and copy number alterations as gain of murine 14q material could be observed. Interestingly, the cell line showed the karyotype 39,X,-X or -Y,t(2;15)(qE5;qD2),del(6)(qB3qC3),del(9)(qA3qA4),dup(14)(qE1qE4) in ~95% of the cells, being exceptionally stable for cell lines being established 38 years ago. Still, ~5% of the cells showed polyploidization followed by chromothripsis. It remains to be determined if this can be observed also in other cell lines, just has not been reported yet, and\/or if it is a unique feature of A-20. Overall, finally here, the necessary genetic data to identify A-20 as a model for human sporadic Burkitt\u2019s lymphoma are provided.<\/jats:p>","DOI":"10.1369\/0022155417731319","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T15:29:05Z","timestamp":1505316545000},"page":"669-677","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Molecular Cytogenetic Characterization Identified the Murine B-Cell Lymphoma Cell Line A-20 as a Model for Sporadic Burkitt\u2019s Lymphoma"],"prefix":"10.1369","volume":"65","author":[{"given":"Karolina","family":"Guja","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany"},{"name":"Department of Plant Anatomy and Cytology, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Liehr","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rincic","sequence":"additional","affiliation":[{"name":"Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda","family":"Kosyakova","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaymaa S.","family":"Hussein Azawi","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"issue":"1","key":"bibr1-0022155417731319","first-page":"24","volume":"4","author":"Cuneo A.","year":"2000","journal-title":"Atlas Genet Cytogenet Oncol Haematol"},{"key":"bibr2-0022155417731319","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(96)80047-3"},{"key":"bibr3-0022155417731319","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2015.1013032"},{"key":"bibr4-0022155417731319","unstructured":"PubMed. 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