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These gastrointestinal dysfunctions might be due to toxic effects of oxaliplatin on the intestinal innervation and glia. Male Balb\/c mice received intraperitoneal injections of sterile water or oxaliplatin (3 mg\/kg\/d) triweekly for 2 weeks. Colon tissues were collected for immunohistochemical assessment at day 14. The density of sensory, adrenergic, and cholinergic nerve fibers labeled with calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH), and vesicular acetylcholine transporter (VAChT), respectively, was assessed within the myenteric plexus of the distal colon. The number and proportion of excitatory neurons immunoreactive (IR) against choline acetyltransferase (ChAT) were counted, and the density of glial subpopulations was determined by using antibodies specific for glial fibrillary acidic protein (GFAP) and s100\u03b2 protein. Oxaliplatin treatment induced significant reduction of sensory and adrenergic innervations, as well as the total number and proportion of ChAT-IR neurons, and GFAP-IR glia, but increased s100\u03b2 expression within the myenteric plexus of the distal colon. Treatment with oxaliplatin significantly alters nerve fibers and glial cells in the colonic myenteric plexus, which could contribute to long-term gastrointestinal side effects following chemotherapeutic treatment.<\/jats:p>","DOI":"10.1369\/0022155418774755","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T10:55:24Z","timestamp":1525863324000},"page":"723-736","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Oxaliplatin Treatment on the Myenteric Plexus Innervation and Glia in the Murine Distal Colon"],"prefix":"10.1369","volume":"66","author":[{"given":"Vanesa","family":"Stojanovska","sequence":"first","affiliation":[{"name":"College of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"McQuade","sequence":"additional","affiliation":[{"name":"College of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Miller","sequence":"additional","affiliation":[{"name":"College of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-6929","authenticated-orcid":false,"given":"Kulmira","family":"Nurgali","sequence":"additional","affiliation":[{"name":"College of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia"},{"name":"Department of Medicine Western Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Regenerative Medicine and Stem Cells Program, Australian Institute for Musculoskeletal Science, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2078-6891.2012.007."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758834011431592."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2004.08.011."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230x-11-65."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i1.25."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2008.11.016."},{"issue":"2","key":"e_1_3_2_10_2","article-title":"Systemic treatment-induced gastrointestinal toxicity: incidence, clinical presentation and management","volume":"25","author":"Boussios S","year":"2012","unstructured":"Boussios S, Pentheroudakis G, Katsanos K, Pavlidis N. 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