{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:42:44Z","timestamp":1791240164535,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"national institute of allergy and infectious diseases","doi-asserted-by":"publisher","award":["R01 AI148695"],"award-info":[{"award-number":["R01 AI148695"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"national institute of allergy and infectious diseases","doi-asserted-by":"publisher","award":["R01 AI148695"],"award-info":[{"award-number":["R01 AI148695"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    Interleukin-33 (IL-33) is an IL-1 family cytokine with pleiotropic effects on diverse cell types. Dysregulated IL-33 signaling has been implicated in pregnancy-related disorders, including preeclampsia and recurrent pregnancy loss, and in ovarian function in women undergoing controlled ovarian stimulation for in vitro fertilization. To date, expression of IL-33 and its receptor subunit, ST2, in the female reproductive tract remains poorly characterized. We identify IL-33-expressing oocytes surrounded by ST2-expressing granulosa cells at all stages of follicular development, in addition to IL-33\n                    <jats:sup>+<\/jats:sup>\n                    and ST2\n                    <jats:sup>+<\/jats:sup>\n                    non-endothelial cells in the ovarian stroma and theca layer in ovaries from adult mice. These expression patterns are similar in estrus- and diestrus-stage adults and in pubescent mice, suggesting a role for IL-33 signaling in ovarian function throughout development and in the estrous cycle. In the uterus, we find expression of IL-33 and ST2 in glandular and luminal epithelia during estrus and at the initiation of pregnancy. Uterine IL-33 expression was modulated by the estrous cycle and was reduced in pubescent females. Last, superovulation increases transcripts for IL-33 and the soluble form of ST2 (sST2) in ovaries, and for IL-33 in uteri. Collectively, our findings lay the foundation for studies identifying cell type-specific requirements for IL-33\/ST2 signaling in the establishment and maintenance of mouse pregnancy.\n                  <\/jats:p>","DOI":"10.1369\/0022155420911049","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T09:24:47Z","timestamp":1582881887000},"page":"253-267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Dynamic Expression of Interleukin-33 and ST2 in the Mouse Reproductive Tract Is Influenced by Superovulation"],"prefix":"10.1369","volume":"68","author":[{"given":"Salma","family":"Begum","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Women\u2019s Health, Rutgers Biomedical and Health Sciences, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry E.","family":"Perlman","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women\u2019s Health, Rutgers Biomedical and Health Sciences, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuriban","family":"Valero-Pacheco","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers Biomedical and Health Sciences, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"O\u2019Besso","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Women\u2019s Health, Rutgers Biomedical and Health Sciences, Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Women\u2019s Health, Rutgers Biomedical and Health Sciences, 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