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As MCs in human seborrheic keratosis (SK) have not been well investigated, here we focused on the MCs in SK. The number of c-Kit and tryptase-positive MCs was significantly increased around the SK compared with the marginal lesion. Degranulated MCs were also increased around the tumors. Furthermore, MC growth factor, stem cell factor (SCF), expression within the SK was significantly upregulated compared with the marginal lesion. Interestingly, one of the cognitive regulators of SCF expression, cannabinoid receptor type 1 (CB1) immunoreactivity was downregulated within the SK. Our results suggest that MCs play important roles in the pathogenesis of SK and that SCF can be also deeply involved in the development of SKs. Our current results highlight the CB1\u2013SCF\u2013MC interaction as a novel mechanism of SK development and this also will be utilized for developing a novel treatment.<\/jats:p>","DOI":"10.1369\/0022155420938031","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T07:43:42Z","timestamp":1592984622000},"page":"461-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Mast Cell\u2013SCF\u2013CB1 Interaction Is a Key Player in Seborrheic Keratosis"],"prefix":"10.1369","volume":"68","author":[{"given":"Mika","family":"Yamanaka-Takaichi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka, Japan (MY-T, KS, RS, DT)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School 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