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HPV infection promotes the epithelial-to-mesenchymal transition (EMT) and transformation of keratinocyte stem cells into cancer stem cells. EMT is a crucial process in the carcinogenesis of epithelial-derived malignancies, and we aimed to study the role of its markers in OPSCC. This study consists of 202 consecutive OPSCC patients diagnosed and treated with curative intent. We examined E-cadherin, \u03b2-catenin, and vimentin expression using immunohistochemistry and compared these with tumor and patient characteristics and treatment outcome. We found that the cell-membranous expression of \u03b2-catenin was stronger in HPV-positive than in HPV-negative tumors, and it was stronger in the presence of regional metastasis. The stromal vimentin expression was stronger among HPV-positive tumors. A high E-cadherin expression was associated with tumor grade. No relationship between these markers and survival emerged. In conclusion, \u03b2-catenin and vimentin seem to play different roles in OPSCC: the former in the tumor tissue itself, and the latter in the tumor stroma. HPV infection may exploit the \u03b2-catenin and vimentin pathways in carcinogenic process. More, \u03b2-catenin may serve as a marker for the occurrence of regional metastasis:<\/jats:p>","DOI":"10.1369\/0022155420950841","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T10:57:01Z","timestamp":1597402621000},"page":"595-606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression and Role of E-Cadherin, \u03b2-Catenin, and Vimentin in Human Papillomavirus\u2013Positive and Human Papillomavirus\u2013Negative Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.1369","volume":"68","author":[{"given":"Hesham","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Department of Histology, Omar Al-Mukhtar University, Al-Bayda, 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