{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:04:05Z","timestamp":1778605445375,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["21H02702"],"award-info":[{"award-number":["21H02702"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Histochem Cytochem."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Angioimmunoblastic T-cell lymphoma (AITL) is a T-cell lymphoma of follicular helper T-cell origin. Histologically, neoplastic T-cells proliferate to form clusters adjacent to or between arborizing high endothelial venules (HEVs). HEVs in normal lymph nodes express sulfated glycans called peripheral lymph node addressin (PNAd); however, it remains unclear whether PNAd is also expressed on HEVs in AITL. Furthermore, although it is widely accepted that HEVs are conspicuous in AITL due to their proliferation, quantitative histological support for this concept is lacking. To investigate these issues, we employed monoclonal antibodies recognizing PNAd, namely, MECA-79, HECA-452, and 297-11A, and performed quantitative immunohistochemical analysis of HEVs in 36 AITL-affected and 67 normal lymph nodes. Staining with all three antibodies confirmed that AITL HEVs express PNAd. Moreover, AITL HEVs were bound calcium-dependently by L-selectin-IgM fusion proteins, indicating that they function in the recruitment of L-selectin-expressing lymphocytes. Unexpectedly, HEV distribution density was not increased but rather decreased in AITL compared with normal lymph nodes, but HEV cross-sectional area in AITL was significantly greater than that seen in normal lymph nodes. Overall, these results indicate that the prominence of AITL HEVs is likely due to increased cross-sectional area rather than increased distribution density.<\/jats:p>","DOI":"10.1369\/00221554211048551","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T12:06:28Z","timestamp":1633608388000},"page":"645-657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Conspicuousness of High Endothelial Venules in Angioimmunoblastic T-cell Lymphoma Is Due to Increased Cross-sectional Area, Not Increased Distribution Density"],"prefix":"10.1369","volume":"69","author":[{"given":"Akiya","family":"Kogami","sequence":"first","affiliation":[{"name":"Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mana","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan"},{"name":"Omachi Municipal General Hospital, Omachi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Komeno","sequence":"additional","affiliation":[{"name":"Department of Hematology, National Hospital Organization Mito Medical Center, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadakazu","family":"Okoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Japanese Red Cross Fukui Hospital, Fukui, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Murahashi","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya O.","family":"Akama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kansai Medical University, Hirakata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Mitoma","sequence":"additional","affiliation":[{"name":"Department of Medical Life Sciences, School of Medical Life Sciences, Kyushu University of Health and Welfare, Nobeoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mito Saiseikai General Hospital, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan"},{"name":"Omachi Municipal General Hospital, Omachi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"bibr1-00221554211048551","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0990-y"},{"key":"bibr2-00221554211048551","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3054"},{"key":"bibr3-00221554211048551","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.55.61"},{"key":"bibr4-00221554211048551","unstructured":"Dogan A, Gaulard P, Jaffe ES, M\u00fcller-Hemelink HK, de Leval L. 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